Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13106
ชื่อเรื่อง: Association of serum high-sensitivity C-reactive protein with metabolic control and diabetic chronic vascular complications in patients with type 2 diabetes
ผู้แต่ง: Chuengsamarn S.
Rattanamongkolgul S.
Sittithumcharee G.
Jirawatnotai S.
Keywords: C reactive protein
glucose
hemoglobin A1c
high density lipoprotein cholesterol
low density lipoprotein cholesterol
triacylglycerol
C reactive protein
glycosylated hemoglobin
hemoglobin A1c protein, human
triacylglycerol
adult
Article
cerebrovascular disease
cholesterol blood level
cohort analysis
coronary artery disease
diabetic nephropathy
diabetic neuropathy
diabetic patient
diabetic retinopathy
female
glucose blood level
hemoglobin blood level
human
laboratory test
major clinical study
male
metabolic regulation
middle aged
non insulin dependent diabetes mellitus
peripheral neuropathy
priority journal
triacylglycerol blood level
aged
blood
complication
diabetic angiopathy
metabolism
non insulin dependent diabetes mellitus
Adult
Aged
Blood Glucose
C-Reactive Protein
Cohort Studies
Diabetes Mellitus, Type 2
Diabetic Angiopathies
Female
Glycated Hemoglobin A
Humans
Male
Middle Aged
Triglycerides
วันที่เผยแพร่: 2017
บทคัดย่อ: Aims To determine an association between hs-CRP and metabolic control/diabetic chronic vascular complications (DCVCCxs) in the patients with type 2 diabetes (DM). In addition, the possibility of using hs-CRP levels to predict risk of DCVCCxs will also be validated. Methods This cohort study randomly enrolled 608 patients with DM during the 2007–2008 study period. We also recorded basic laboratory findings at baseline and at one year, to include fasting plasma glucose, HbA1c, triglyceride, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and hs-CRP. Results Logistic regressions of odds ratios between hs-CRP and DCVCCxs (coronary arterial disease, cerebrovascular disease, diabetic nephropathy, diabetic retinopathy, and diabetic peripheral neuropathy) showed significant correlations, except for cerebrovascular disease, as follows 0.2 (0.11–0.38), 0.09 (0.01–0.77), 0.06 (0.02–0.16), 0.31 (0.12–0.82), and 0.17 (0.07–0.43), respectively. Linear regression for changes in hs-CRP were significantly correlated with HbA1c (r = 0.38), fasting plasma glucose (r = 0.40), triglyceride (r = 0.20), low-density lipoprotein cholesterol (r = 0.12), and high-density lipoprotein cholesterol (r = −0.12). No correlation was found for total cholesterol (r = 0.06). Based on receiver operating characteristic (ROC) analysis, the cut-off points for hs-CRP levels for prediction of DCVCCxs were 2.89, 2.25, 2.10, 2.25, and 2.82 mg/L, for coronary arterial disease, cerebrovascular disease, diabetic nephropathy, diabetic retinopathy, and diabetic peripheral neuropathy, respectively. Conclusions Our data showed that DCVCCxs were associated with hs-CRP in patients with DM. The cut-off point for hs-CRP can be used to predict association with DCVCCxs. Well-controlled metabolic components in diabetic patients, especially HbA1c, fasting plasma glucose, and triglyceride may reduce the level of hs-CRP. © 2016 Diabetes India
URI: https://ir.swu.ac.th/jspui/handle/123456789/13106
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85008627653&doi=10.1016%2fj.dsx.2016.08.012&partnerID=40&md5=dc7e4bc70fe517b0c4cc10bc3e0ab2c0
ISSN: 18714021
Appears in Collections:Scopus 1983-2021

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