Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13027
ชื่อเรื่อง: Semisynthesis and biological evaluation of prenylated resveratrol derivatives as multi-targeted agents for Alzheimer’s disease
ผู้แต่ง: Puksasook T.
Kimura S.
Tadtong S.
Jiaranaikulwanitch J.
Pratuangdejkul J.
Kitphati W.
Suwanborirux K.
Saito N.
Nukoolkarn V.
Keywords: 3 ethoxy 4',5 hydroxystilbene
3 methoxy 4',5 hydroxystilbene
3,4' diethoxy 5 hydroxystilbene
3,4' dimethoxy 5 hydroxystilbene
3,5,4' tri(methoxymethoxy) 4 prenylstilbene
3,5,4' tri(methoxymethoxy)stilbene
3,5,4' triethoxystilbene
3,5,4' trihydroxy 2 geranylstilbene
3,5,4' trihydroxy 2 prenylstilbene
3,5,4' trihydroxy 2,6 geranylstilbene
3,5,4' trihydroxy 2,6 prenylstilbene
3,5,4' trihydroxy 4 geranylstilbene
3,5,4' trihydroxy 4 prenylstilbene
3,5,4' trimethoxystilbene
4' ethoxy 3,5 dihydroxystilbene
4' methoxy 3,5 dihydroxystilbene
ascorbic acid
beta secretase
beta secretase inhibitor
calbiochem
curcumin
quercetin
resveratrol
unclassified drug
amyloid beta protein
antioxidant
neuroprotective agent
plant extract
resveratrol
secretase
stilbene derivative
Alzheimer disease
animal cell
antioxidant activity
Article
cell viability
cell viability assay
controlled study
drug structure
drug synthesis
embryo
IC50
molecular docking
mouse
nerve cell
nerve cell differentiation
neurite
neuroprotection
nonhuman
oxidative stress
P19 cell line
Alzheimer disease
antagonists and inhibitors
cell culture technique
drug effects
human
metabolism
prenylation
Alzheimer Disease
Amyloid beta-Peptides
Amyloid Precursor Protein Secretases
Antioxidants
Cell Culture Techniques
Humans
Neurites
Neurons
Neuroprotective Agents
Oxidative Stress
Plant Extracts
Prenylation
Stilbenes
วันที่เผยแพร่: 2017
บทคัดย่อ: Abstract: A series of prenylated resveratrol derivatives were designed, semisynthesized and biologically evaluated for inhibition of β-secretase (BACE1) and amyloid-β (Aβ) aggregation as well as free radical scavenging and neuroprotective and neuritogenic activities, as potential novel multifunctional agents against Alzheimer’s disease (AD). The results showed that compound 4b exhibited good anti-Aβ aggregation (IC50 = 4.78 µM) and antioxidant activity (IC50 = 41.22 µM) and moderate anti-BACE1 inhibitory activity (23.70% at 50 µM), and could be a lead compound. Moreover, this compound showed no neurotoxicity along with a greater ability to inhibit oxidative stress on P19-derived neuronal cells (50.59% cell viability at 1 nM). The neuritogenic activity presented more branching numbers (9.33) and longer neurites (109.74 µm) than the control, and was comparable to the quercetin positive control. Taken together, these results suggest compound 4b had the greatest multifunctional activities and might be a very promising lead compound for the further development of drugs for AD. © 2017, The Japanese Society of Pharmacognosy and Springer Japan.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13027
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020739007&doi=10.1007%2fs11418-017-1097-2&partnerID=40&md5=8a2e6fd289b5bed462c517bd1053551c
ISSN: 13403443
Appears in Collections:Scopus 1983-2021

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