Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13021
ชื่อเรื่อง: Acute inhibitory effect of alpha-mangostin on sarcoplasmic reticulum calcium-ATPase and myocardial relaxation
ผู้แต่ง: Phungphong S.
Kijtawornrat A.
de Tombe P.P.
Wattanapermpool J.
Bupha-Intr T.
Suksamrarn S.
Keywords: adenosine triphosphatase (calcium)
adenosine triphosphatase (magnesium)
alpha mangostin
calcium ion
dimethyl sulfoxide
sarcoplasmic reticulum calcium transporting adenosine triphosphatase
unclassified drug
xanthone derivative
mangostin
sarcoplasmic reticulum calcium transporting adenosine triphosphatase
xanthone derivative
adult
animal cell
animal experiment
animal tissue
Article
cardiac muscle cell
cell isolation
concentration response
dose response
drug dose comparison
drug specificity
enzyme inhibition
heart left ventricle pressure
heart left ventricle relaxation
heart muscle relaxation
in vitro study
in vivo study
male
nonhuman
rat
animal
antagonists and inhibitors
cardiac muscle
diastole
drug effects
heart ventricle
Leporidae
metabolism
pathophysiology
Animals
Diastole
Heart Ventricles
Male
Myocardium
Myocytes, Cardiac
Rabbits
Sarcoplasmic Reticulum Calcium-Transporting ATPases
Xanthones
วันที่เผยแพร่: 2017
บทคัดย่อ: The benefits of α-mangostin for various tissues have been reported, but its effect on the heart has not been clarified. This study aimed to evaluate the effects of α-mangostin on cardiac function. Using a cardiac sarcoplasmic reticulum (SR) membrane preparation, α-mangostin inhibited SR Ca2+-ATPase activity in a dose-dependent manner (IC50 of 6.47 ± 0.7 μM). Its suppressive effect was specific to SR Ca2+-ATPase but not to myofibrillar Ca2+-ATPase. Using isolated cardiomyocytes, 50 μM of α-mangostin significantly increased the duration of cell relengthening and increased the duration of Ca2+ transient decay, suggesting altered myocyte relaxation. The relaxation effect of α-mangostin was also supported in vivo after intravenous infusion. A significant suppression of both peak pressure and rate of ventricular relaxation (–dP/dt) relative to DMSO infusion was observed. The results from the present study demonstrated that α-mangostin exerts specific inhibitory action on SR Ca2+-ATPase activity, leading to myocardial relaxation dysfunction. © 2017 Wiley Periodicals, Inc.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13021
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020256751&doi=10.1002%2fjbt.21942&partnerID=40&md5=09ca837c52a5416a4bc27861793e15e0
ISSN: 10956670
Appears in Collections:Scopus 1983-2021

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