Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/12872
ชื่อเรื่อง: Clinical outcomes of minimized hydrocortisone dosage of 100mg/day on lower occurrence of hyperglycemia in septic shock patients
ผู้แต่ง: Ngaosuwan K.
Ounchokdee K.
Chalermchai T.
Keywords: dopamine
epinephrine
glucose
hydrocortisone sodium succinate
noradrenalin
hydrocortisone
adult
Article
clinical outcome
controlled study
double blind procedure
drug dose reduction
drug dose titration
drug fatality
drug withdrawal
female
fluid therapy
gastrointestinal hemorrhage
glucose blood level
human
hyperglycemia
major clinical study
male
mortality rate
outcome assessment
parallel design
randomized controlled trial
recommended drug dose
septic shock
Simplified Acute Physiology Score
superinfection
aged
blood
complication
disease free survival
gastrointestinal hemorrhage
hyperglycemia
middle aged
mortality
survival rate
time factor
very elderly
Aged
Aged, 80 and over
Disease-Free Survival
Double-Blind Method
Female
Gastrointestinal Hemorrhage
Humans
Hydrocortisone
Hyperglycemia
Male
Middle Aged
Shock, Septic
Survival Rate
Time Factors
วันที่เผยแพร่: 2018
บทคัดย่อ: Background: The current international guideline recommended 200 mg/day of hydrocortisone intravenously to treat septic shock. However, a subsequent study on cortisol metabolism actually showed an increase in cortisol level during sepsis. Hence, the smaller hydrocortisone dose of 100 mg/day might be sufficient and reduce steroid-associated complications. We aimed to compare the clinical outcomes of minimized hydrocortisone dose of 100mg to the currently recommended dose in the treatment of septic shock patients. Methods: A double-blinded randomized controlled trial included 80 septic shock patients with hemodynamic instability despite fluid and vasopressive therapy. Participants were divided equally into two groups to treat with 100 mg/day or 200 mg/day of hydrocortisone, then stepwise down titrated and discontinued on day 8. The outcome of interest was the hyperglycemic rate. Vital status, time to shock reversal, superinfection and gastrointestinal bleeding rates were also compared. Results: Patients with 100mg hydrocortisone had significantly lower hyperglycemic rate compared with 200 mg, 63.9% versus 86.5% (the adjusted hazard ratio [HR], 0.08; 95% confidence interval [CI], 0.02-0.41, P=0.002). Time to shock reversal was shorter in patients with 100mg hydrocortisone, 2 days vs. 4 days, P=0.031. The 28-day mortality rate when adjusted for Simplified Acute Physiology Score II showed no significant difference (HR, 0.68; 95% CI, 0.37-1.24, P=0.209). The reinfection and gastrointestinal bleeding rates were comparable between groups. Conclusion: Minimized daily hydrocortisone dosage of 100mg could lower the occurrence of hyperglycemia without increasing mortality in septic shock, compared with the currently recommended dosage of 200 mg/day. Copyright © 2017 by the Shock Society.
URI: https://ir.swu.ac.th/jspui/handle/123456789/12872
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85051031361&doi=10.1097%2fSHK.0000000000001061&partnerID=40&md5=38344b0773047b0f1858ecffea3e6187
ISSN: 10732322
Appears in Collections:Scopus 1983-2021

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