Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/12800
ชื่อเรื่อง: Hematologic malignancies associated with mediastinal germ cell tumors: 10 years' experience at Thailand's national pediatric tertiary referral center
ผู้แต่ง: Sowithayasakul P.
Sinlapamongkolkul P.
Treetipsatit J.
Vathana N.
Narkbunnam N.
Sanpakit K.
Buaboonnam J.
Keywords: alpha fetoprotein
bleomycin
carboplatin
chorionic gonadotropin beta subunit
cisplatin
etoposide
ifosfamide
lactate dehydrogenase
mesna
acute myeloid leukemia
adolescent
Article
body weight loss
bone marrow biopsy
cancer incidence
cancer survival
child
chronic cough
clinical article
clinical feature
clinical protocol
controlled study
correlation analysis
cytogenetics
disease association
disease course
fever
flow cytometry
germ cell tumor
granulocytic sarcoma
hematologic malignancy
hemophagocytic syndrome
human
human tissue
lung function
male
priority journal
protein blood level
retrospective study
school child
tertiary care center
Thailand
acute myeloid leukemia
granulocytic sarcoma
hematologic disease
mediastinum tumor
mortality
neoplasm
second cancer
Adolescent
Hematologic Neoplasms
Humans
Leukemia, Myeloid, Acute
Male
Mediastinal Neoplasms
Neoplasms, Germ Cell and Embryonal
Neoplasms, Second Primary
Retrospective Studies
Sarcoma, Myeloid
Tertiary Care Centers
Thailand
วันที่เผยแพร่: 2018
บทคัดย่อ: Mediastinal germ cell tumor (MGCT), which accounts for 1% to 3% of extragonadal germ cell tumors, has unique manifestations; it is associated with several types of hematologic malignancy, particularly myeloid neoplasm. The aim of this study was to report the 10-year incidence, clinical characteristics, and outcomes of MGCT at Thailand's national pediatric tertiary referral center. This retrospective study included patients diagnosed with MGCT at the Department of Pediatrics, Siriraj Hospital during 2005 to 2014. Eight patients (all male) were diagnosed with MGCT. Five of 8 patients were found to have hematologic abnormalities. Three patients were diagnosed with acute myeloid leukemia (AML) (one patient with M1, another having M7, and the other with M0). Another patient had mixed MGCT with mediastinal myeloid sarcoma (MMS). The other patient had malignancy-associated hemophagocytic lymphohistiocytosis syndrome (M-HLH). Isochromosome 12p was detected in 3 patients (AML [2], mixed MGCT/MMS [1]). Four of 5 patients with hematologic abnormalities died of hematologic abnormalities or treatment complication (AML [3], M-HLH [1]). One patient with mixed MGCT/MMS survived with chemotherapy. All patients with AML and MMS were nonseminomatous MGCT and the onset of myeloid malignancies were within 1 year after the diagnosis of MGCT. Associated hematologic malignancies should be suspected in MGCT with abnormal blood count or hematologic symptoms. Isochromosome 12p was the most common cytogenetic finding in MGCT-associated myeloid malignancies patients. Those with nonseminomatous MGCT should have their blood count carefully monitored especially during the first year after the diagnosis of MGCT. Better treatment alternatives for MGCT with associated hematologic malignancies are warranted to ameliorate adverse outcomes. © 2018 Wolters Kluwer Health, Inc. All rights reserved.
URI: https://ir.swu.ac.th/jspui/handle/123456789/12800
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048282530&doi=10.1097%2fMPH.0000000000001233&partnerID=40&md5=75c9c47f8344b7f5ae0a76f3b34c6be8
ISSN: 10774114
Appears in Collections:Scopus 1983-2021

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