Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/12671
ชื่อเรื่อง: Increased Plasma Osteocalcin, Oral Disease, and Altered Mandibular Bone Density in Postmenopausal Women
ผู้แต่ง: Thanakun S.
Pornprasertsuk-Damrongsri S.
Na Mahasarakham C.P.
Techatanawat S.
Izumi Y.
Keywords: osteocalcin
adult
alveolar bone loss
Article
body mass
bone density
comparative study
controlled study
dental patient
enzyme linked immunosorbent assay
female
human
hypercholesterolemia
impaired glucose tolerance
major clinical study
mandible
middle aged
mucosal dryness
obesity
oral mucosal disease
osteopenia
osteoporosis
postmenopause
second premolar
tooth periapical disease
xerostomia
วันที่เผยแพร่: 2019
บทคัดย่อ: An association between oral diseases and postmenopausal status has been recognized. However, the relationship between all oral disease, mandibular bone density, health status, and osteocalcin (OCN) bone markers in postmenopausal dental patients has not been reported. This study was therefore to verify the differences in plasma OCN levels, dental, periodontal, and oral mucosal disease, and mandibular bone density alterations from panoramic radiograph and systemic parameters in postmenopausal women, compared to premenopausal women. Oral, radiographic, and blood examination were performed in 92 females. Dental, periodontal, and oral mucosal statuses were recorded. Health profile parameters were collected from medical charts. Plasma OCN was evaluated by enzyme-linked immunosorbent assay. Forty-two (45.7%) participants were postmenopausal with a higher median age (55 (51, 62) years) than the premenopausal group (43 (38, 45) years). Overweight or obesity, hypercholesterolemia, and impaired fasting blood sugar were more prevalent in postmenopause. The average postmenopausal OCN level (425.62 ng/mL) was significantly higher than the premenopausal group (234.77 ng/mL, p<0.001). The average number of missing teeth, mean attachment loss, alveolar bone loss, periapical lesion count, and clinical oral dryness score were also significantly higher in postmenopause (p=0.008, <0.001, 0.031, 0.006, and 0.005, respectively). However, mandibular bone density determined by mandibular cortical index was lower in postmenopause (p<0.001). The panoramic mandibular index, mandibular cortical width, fractal dimension, and other oral mucosal disease did not differ between the groups. Postmenopause was associated with elevated plasma OCN (β = 0.504, p<0.001) when related covariates were adjusted. Elevated plasma OCN, oral mucosal dryness, high number of periapical radiolucencies and missing teeth, and lower mandibular bone density from panoramic radiograph were prevalent in postmenopausal women. Dentists should suspect an increased risk of low bone mineral density in postmenopausal patients who display these clinical and radiographic findings, and they should be referred for further examination. Plasma OCN may interconnect a relationship between postmenopausal status and the low mandibular bone density. © 2019 Supanee Thanakun et al.
URI: https://ir.swu.ac.th/jspui/handle/123456789/12671
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85075338037&doi=10.1155%2f2019%2f3715127&partnerID=40&md5=92ef109bf68808350a534b61783f4937
ISSN: 16878728
Appears in Collections:Scopus 1983-2021

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