Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/12604
ชื่อเรื่อง: Phikud Navakot Modulates the Level of Pro-Inflammatory Mediators and the Protein Expression of SOD1 and 2 and the Nrf2/HO-1 Signaling Pathway in Rats with Acute Myocardial Infarction
ผู้แต่ง: Gerdprasert O.
Choomchuay N.
Chantong B.
Sutanthavibul N.
Meksuriyen D.
Nusuetrong P.
Keywords: alcohol
antiinflammatory agent
antioxidant
cardiovascular agent
catalase
copper zinc superoxide dismutase
glutathione peroxidase
heme oxygenase 1
herbaceous agent
interleukin 6
manganese superoxide dismutase
phikud navakot
propranolol
protective agent
transcription factor Nrf2
troponin T
tumor necrosis factor
unclassified drug
acute heart infarction
animal experiment
animal model
animal tissue
antiinflammatory activity
antioxidant activity
Article
cell infiltration
controlled study
cytokine release
drug dose comparison
drug efficacy
drug mechanism
edema
enzyme activity
ethnopharmacology
heart muscle injury
heart muscle necrosis
heart protection
heart tissue
inflammation
inflammatory cell
inflammatory infiltrate
interstitial edema
isoproterenol-induced myocardial infarction
male
mediator release
nonhuman
oxidative stress
protein blood level
protein expression
rat
signal transduction
ST segment
tissue necrosis
upregulation
วันที่เผยแพร่: 2019
บทคัดย่อ: Phikud Navakot (PN) is nine major herbs in a famous traditional Thai recipe namely "Yahom Navakot" used to treat cardiovascular disorders. This study investigated the cardioprotective effects of PN formula on isoproterenol-induced myocardial infarction (IMI) in Sprague-Dawley rats. Forty-five rats were randomly divided into nine groups (n = 5 per group): the control, the IMI, the IMI + propranolol, the control or the IMI + PN formula (PN ethanolic extract at doses of 64, 127, or 255 mg/kg) by oroesophageal gavage for 28 days. The ST segment and serum troponin T levels were significantly increased in IMI rats. PN did not eliminate tissue necrosis, infiltration of inflammatory cells, or interstitial edema in IMI rats. All doses of PN decreased (p<0.001) serum TNF-α and IL-6 levels. PN (127 and 255 mg/kg) up-regulated (p<0.05) heme oxygenase (HO)-1 expression, whereas PN (255 mg/kg) significantly increased superoxide dismutase (SOD) 1 and 2 expression, compared with IMI rats. Nuclear factor erythroid 2-related factor 2 (Nrf2) and HO-1 expression significantly increased in IMI rats and IMI rats that received PN. PN formula possesses potential anti-inflammatory and antioxidant properties by modulating the levels of TNF-α, IL-6 and antioxidant enzymes. Our study reveals a novel cardioprotective effect of PN in IMI rats through the Nrf2/HO-1 signaling. © 2019 Orapin Gerdprasert et al.
URI: https://ir.swu.ac.th/jspui/handle/123456789/12604
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85073078632&doi=10.1155%2f2019%2f4823645&partnerID=40&md5=a21832711209112cb0d6f5353f0ff099
ISSN: 1741427X
Appears in Collections:Scopus 1983-2021

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