Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/12577
ชื่อเรื่อง: Pregnancies after Childhood Craniopharyngioma: Results of KRANIOPHARYNGEOM 2000/2007 and Review of the Literature
ผู้แต่ง: Sowithayasakul P.
Boekhoff S.
Bison B.
Müller H.L.
Keywords: chorionic gonadotropin
desmopressin
gonadorelin agonist
human menopausal gonadotropin
hydrocortisone
levothyroxine
adolescent
adrenal insufficiency
adult
Article
birth weight
body mass
cancer patient
cancer radiotherapy
cesarean section
childhood cancer
clinical outcome
craniopharyngioma
diabetes insipidus
fatigue
female
female fertility
gestational age
growth rate
headache
human
hypopituitarism
hypothyroidism
infertility therapy
major clinical study
male
neuroimaging
non insulin dependent diabetes mellitus
nuclear magnetic resonance imaging
observational study
ovulation induction
perinatal period
postoperative care
precocious puberty
pregnancy
pregnancy complication
pregnancy rate
premature labor
prematurity
priority journal
progeny
solid malignant neoplasm
tumor volume
vaginal delivery
young adult
วันที่เผยแพร่: 2020
บทคัดย่อ: Data on female fertility, pregnancy, and outcome of offspring after childhood-onset craniopharyngioma (CP) are rare. Study Design: Observational study on pregnancy rate and offspring outcome in female CP patients recruited in KRANIOPHARYNGEOM 2000/2007 since 2000. Results: A total of 451 CP patients (223 female) have been recruited, and 269 (133 female) were postpubertal at study. Six of 133 female CP patients (4.5%) with a median age of 14.9 years at CP diagnosis had 9 pregnancies, giving birth to 10 newborns. Three patients achieved complete surgical resections. No patient underwent postoperative irradiation. Five natural pregnancies occurred in 3 CP patients without pituitary deficiencies. Four pregnancies in 3 CP patients with hypopituitarism were achieved under assisted reproductive techniques (ART) (median 4.5 cycles, range: 3-6 cycles). Median maternal age at pregnancy was 30 years (range: 22-41 years). Six babies (60%) were delivered by caesarean section. Median gestational age at delivery was 38 weeks (range: 34-43 weeks); median birth weight was 2,920 g (range: 2,270-3,520 g), the rate of preterm delivery was 33%. Enlargements of CP cysts occurred in 2 women during pregnancy. Other complications during pregnancy, delivery, and postnatal period were not observed. Conclusions: Pregnancies after CP are rare and were only achieved after ART in patients with hypopituitarism. Close monitoring by an experienced reproductive physician is necessary. Due to a potentially increased risk for cystic enlargement, clinical, ophthalmological, and MRI monitoring are recommended in patients at risk. Severe perinatal complications, birth defects, and postnatal morbidity of mothers and offspring were not observed. © 2020
URI: https://ir.swu.ac.th/jspui/handle/123456789/12577
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098219902&doi=10.1159%2f000506639&partnerID=40&md5=77a3bc797c09ad067f169554ce83f199
ISSN: 283835
Appears in Collections:Scopus 1983-2021

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