Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/12497
Title: Nitrogen plasma skin regeneration for the treatment of mild-to-moderate periorbital wrinkles: A prospective, randomized, controlled evaluator-blinded trial
Authors: Theppornpitak N.
Udompataikul M.
Chalermchai T.
Ophaswongse S.
Limtanyakul P.
Keywords: nitrogen
nitrogen
adult
Article
clinical effectiveness
controlled study
disease severity
dry skin
erythema
esthetics
eye photography
female
general condition improvement
human
human experiment
hyperpigmentation
Lemperle scale
male
melanin index
middle aged
normal human
pain assessment
patient safety
patient satisfaction
periorbital wrinkle
plasma skin regeneration
priority journal
prospective study
pruritus
randomized controlled trial
scaling
single blind procedure
skin disease
skin disease assessment
skin wrinkle score
treatment duration
treatment planning
wrinkle
cutaneous parameters
drug effect
esthetic surgery
eye
functions of the skin and its appendages
regeneration
treatment outcome
Adult
Cosmetic Techniques
Eye
Female
Humans
Male
Middle Aged
Nitrogen
Patient Satisfaction
Prospective Studies
Regeneration
Single-Blind Method
Skin Aging
Skin Physiological Phenomena
Treatment Outcome
Issue Date: 2019
Abstract: Background: Nitrogen plasma skin regeneration is a novel device that produces heat to the skin, resulting in the production of new collagen. Because of lower energy with safer skin damage and lesser adverse effects who have high Fitzpatrick's skin type especially Thais, this technique is very interesting for clinical application for skin esthetic treatment. However, this treatment has yet been empirically studied as the treatment for mild-to-moderate periorbital wrinkles. Objectives: This study aimed to evaluate clinical efficacy of nitrogen plasma for the treatment of mild-to-moderate periorbital wrinkles. Methods: Eighteen volunteers were enrolled. Each volunteer was randomized to receive nitrogen plasma treatment on one side of periorbital wrinkles with three sessions at a three-week interval and compared with contralateral side without treatment. Photographic examination, skin wrinkle (SEw) score, melanin index, patients' satisfaction score, side effect, and pain score were reported. Results: At over fourteen weeks, all volunteers completed the study. Treatment with nitrogen plasma group had significantly better improvement for periorbital wrinkles score by Lemperle scale, skin wrinkle (SEw) score by Visioscan® VC 98, and the melanin index by Mexameter® than the control groups (P = 0.004, P < 0.001, P < 0.001, respectively). This study also showed significantly greater satisfaction score to favor the nitrogen plasma treatment group than the control group (P < 0.001). The short-term adverse effects included erythema, scaling, temporary hyperpigmentation, pruritus, and dryness. Conclusion: Nitrogen plasma skin regeneration is effective and safe for the treatment of mild-to-moderate periorbital wrinkles and darkening. © 2018 Wiley Periodicals, Inc.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052462913&doi=10.1111%2fjocd.12767&partnerID=40&md5=3b38680adce18b5f67ee254fee6ddffc
http://ir.swu.ac.th/jspui/handle/123456789/12497
ISSN: 14732130
Appears in Collections:Scopus 1983-2021

Files in This Item:
There are no files associated with this item.


Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.