Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/12486
ชื่อเรื่อง: Cost effectiveness analysis of HPV primary screening and dual stain cytology triage compared with cervical cytology
ผู้แต่ง: Termrungruanglert W.
Khemapech N.
Tantitamit T.
Havanond P.
Keywords: Ki 67 antigen
protein p16
virus DNA
adult
aged
Article
cancer incidence
cancer mortality
cohort analysis
controlled study
cost effectiveness analysis
cost of illness
diagnostic test accuracy study
emergency health service
female
human
human cell
intermethod comparison
major clinical study
mortality rate
Papanicolaou test
papillomavirus infection
precancer
prevalence
quality adjusted life year
screening test
sensitivity and specificity
staining
uterine cervix cancer
uterine cervix cytology
comparative study
cost benefit analysis
early cancer diagnosis
economic model
economics
epidemiology
genetics
genotype
Human papillomavirus type 16
Human papillomavirus type 18
isolation and purification
middle aged
mortality
procedures
Thailand
uterine cervix carcinoma in situ
uterine cervix tumor
vagina smear
virology
Adult
Aged
Cervical Intraepithelial Neoplasia
Cost-Benefit Analysis
DNA, Viral
Early Detection of Cancer
Female
Genotype
Human papillomavirus 16
Human papillomavirus 18
Humans
Middle Aged
Models, Economic
Quality-Adjusted Life Years
Sensitivity and Specificity
Thailand
Uterine Cervical Neoplasms
Vaginal Smears
วันที่เผยแพร่: 2019
บทคัดย่อ: Objectives: To assess the clinical and cost-effectiveness of human papillomavirus (HPV) primary screening triage with p16/Ki-67 dual stain cytology compared to cytology. Methods: We conducted an Excel®-based budget impact model to estimate the preinvasive and invasive cervical cancer cases identified, mortality rate, direct medical costs, quality-adjusted life years (QALYs) and the incremental cost-effectiveness analysis of two strategies from the healthcare payer perspective. The study population is a cohort of women 30-65 years of age presenting for cervical screening. Results: HPV primary screening triage with p16/Ki-67 dual stain showed higher sensitivity without losing specificity compared to conventional Pap smear. The improving the screening performance leads to decrease the prevalence of precancerous lesion, annual incidence and mortality of cervical cancer. The incidence of cervical cancer case detected by new algorithm compared with conventional method were 31,607 and 38,927, respectively. In addition, the new algorithm was more effective and more costly (average QALY 24.03, annual cost $13,262,693) than conventional cytology (average QALY 23.98, annual cost $7,713,251). The incremental cost-effective ratio (ICER) per QALY gained was $1,395. The sensitivity analysis showed if the cost of cytology and HPV test increased three times, the ICER would fall to $303/QALY gained and increased to $4,970/QALY gained, respectively. Conclusion: Our model results suggest that screening by use of HPV genotyping test as a primary screening test combined with dual stain cytology as the triage of HPV positive women in Thai population 30-65 years old is expected to be more cost-effective than conventional Pap cytology. © 2019. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology.
URI: https://ir.swu.ac.th/jspui/handle/123456789/12486
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062185437&doi=10.3802%2fjgo.2019.30.e17&partnerID=40&md5=64d6329e8637cb84fad10686d3ad24de
ISSN: 20050380
Appears in Collections:Scopus 1983-2021

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