Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/12394
ชื่อเรื่อง: Correlating Changes in the Macular Microvasculature and Capillary Network to Peripheral Vascular Pathologic Features in Familial Exudative Vitreoretinopathy
ผู้แต่ง: Koulisis N.
Moysidis S.N.
Yonekawa Y.
Dai Y.L.
Burkemper B.
Wood E.H.
Lertjirachai I.
Todorich B.
Khundkar T.Z.
Chu Z.
Wang R.K.
Williams G.A.
Drenser K.A.
Capone A.
Jr.
Trese M.T.
Nudleman E.
Keywords: adolescent
adult
arteriovenous shunt
Article
B scan
best corrected visual acuity
blood vessel diameter
child
comparative study
controlled study
deep retinal layer
disease severity
eye disease
familial exudative vitreoretinopathy
female
fluorescence angiography
foveal avascular zone
fractal dimension
human
late phase angiographic posterior and peripheral vascular leakage
macular microvasculature
major clinical study
multicenter study
observational study
optical coherence tomography angiography
peripheral vascular system
prevalence
priority journal
pulmonary arteriovenous fistula
quantitative analysis
retina blood vessel
retrospective study
skeletal density
superficial retinal layer
vascular dragging
vascular tortuosity
vessel density
vessel diameter index
visual system parameters
vitreoretinopathy
วันที่เผยแพร่: 2019
บทคัดย่อ: Purpose: To evaluate the macular microvasculature in patients with familial exudative vitreoretinopathy (FEVR) using OCT angiography (OCTA) and to assess for peripheral vascular changes using widefield fluorescein angiography (WFA). Design: Multicenter, retrospective, comparative, observational case series. Participants: We identified 411 patients with FEVR, examined between September 2014 and June 2018. Fifty-seven patients with FEVR and 60 healthy controls had OCTA images of sufficient quality for analysis. Methods: Custom software was used to assess for layer-specific, quantitative changes in vascular density and morphologic features on OCTA by way of vessel density (VD), skeletal density (SD), fractal dimension (FD), vessel diameter index (VDI), and foveal avascular zone (FAZ). Widefield fluorescein angiography images were reviewed for peripheral vascular changes including capillary dropout, late-phase angiographic posterior and peripheral vascular leakage (LAPPEL), vascular dragging, venous–venous shunts, and arteriovenous shunts. Main Outcome Measures: Macular microvascular parameters on OCTA and peripheral angiographic findings on WFA. Results: OCT angiography analysis of 117 patients (187 eyes; 92 FEVR patients and 95 control participants) demonstrated significantly reduced VD, SD, and FD and greater VDI in patients with FEVR compared with controls in the nonsegmented retina, superficial retinal layer (SRL), and deep retinal layer (DRL). The FAZ was larger compared with that in control eyes in the DRL (P < 0.0001), but not the SRL (P = 0.52). Subanalysis by FEVR stage showed the same microvascular changes compared with controls for all parameters. Widefield fluorescein angiography analysis of 95 eyes (53 patients) with FEVR demonstrated capillary nonperfusion in all eyes: 47 eyes (49.5%) showed LAPPEL, 32 eyes (33.7%) showed vascular dragging, 30 eyes (31.6%) had venous–venous shunts, and 33 eyes (34.7%) had arteriovenous shunts. Decreasing macular VD on OCTA correlated with increasing peripheral capillary nonperfusion on WFA. Decreasing fractal dimension on OCTA correlated with increasing LAPPEL severity on WFA. Conclusions: Patients with FEVR demonstrated abnormalities in the macular microvasculature and capillary network, in addition to the peripheral retina. The macular microvascular parameters on OCTA may serve as biomarkers of changes in the retinal periphery on WFA. © 2019
URI: https://ir.swu.ac.th/jspui/handle/123456789/12394
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85070434906&doi=10.1016%2fj.oret.2019.02.013&partnerID=40&md5=ed71c85a5fb7c7c2e5c2390d4485d7eb
ISSN: 24686530
Appears in Collections:Scopus 1983-2021

Files in This Item:
There are no files associated with this item.


Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.