Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/12391
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dc.contributor.authorPinyorospathum C.
dc.contributor.authorChaiyo S.
dc.contributor.authorSae-ung P.
dc.contributor.authorHoven V.P.
dc.contributor.authorDamsongsang P.
dc.contributor.authorSiangproh W.
dc.contributor.authorChailapakul O.
dc.date.accessioned2021-04-05T03:03:09Z-
dc.date.available2021-04-05T03:03:09Z-
dc.date.issued2019
dc.identifier.issn263672
dc.identifier.other2-s2.0-85068000894
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85068000894&doi=10.1007%2fs00604-019-3559-6&partnerID=40&md5=1c3e784e8c7cf5fda9302d3bf2efaf98
dc.identifier.urihttp://ir.swu.ac.th/jspui/handle/123456789/12391-
dc.description.abstractA paper-based electrochemical sensor is described that is based on the use of thiol-terminated poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC-SH) that was self-assembled on a gold nanoparticle-modified screen-printed electrode (SPE). The SPE sensor was used for label-free detection of C-reactive protein (CRP). Gold nanoparticles (AuNPs) were first electrodeposited on the SPCE, followed by the self-assembly of PMPC-SH on gold. The electrochemical response of the modified SPE to CRP was measured by differential pulse voltammetry (DPV). If the CRP on the paper device is contacted with Ca (II) ions, the current (measured by using hexacyanoferrate as the electrochemical probe) decreases. The signal drops in the 5 to 5000 ng·mL−1 CRP concentration range, and the lower detection limit (at 3 SD/slope) is 1.6 ng·mL−1. The use of a PMPC-modified surface also reduces the nonspecific adsorption of proteins. The sensor is not interfered by bilirubin, myoglobin and albumin. It was successfully applied to CRP detection in certified human serum. This sensor is applicable as an attractive protocol for an inexpensive, highly sensitive, and disposable material for electrochemical detection of CRP. [Figure not available: see fulltext.]. © 2019, Springer-Verlag GmbH Austria, part of Springer Nature.
dc.subjectC reactive protein
dc.subjectgold
dc.subjectmetal nanoparticle
dc.subjectphosphorylcholine
dc.subjectpoly(2-methacryloyloxyethyl-phosphorylcholine)
dc.subjectpolymethacrylic acid derivative
dc.subjectthiol derivative
dc.subjectchemistry
dc.subjectdevices
dc.subjectelectrochemical analysis
dc.subjectelectrode
dc.subjecthuman
dc.subjectlimit of detection
dc.subjectpaper
dc.subjectprocedures
dc.subjectC-Reactive Protein
dc.subjectElectrochemical Techniques
dc.subjectElectrodes
dc.subjectGold
dc.subjectHumans
dc.subjectLimit of Detection
dc.subjectMetal Nanoparticles
dc.subjectPaper
dc.subjectPhosphorylcholine
dc.subjectPolymethacrylic Acids
dc.subjectSulfhydryl Compounds
dc.titleDisposable paper-based electrochemical sensor using thiol-terminated poly(2-methacryloyloxyethyl phosphorylcholine) for the label-free detection of C-reactive protein
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationMicrochimica Acta. Vol 186, No.7 (2019)
dc.identifier.doi10.1007/s00604-019-3559-6
Appears in Collections:Scopus 1983-2021

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