Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/11905
ชื่อเรื่อง: Strong variance in the inflammatory and cytotoxic potentials of Penicillium and Aspergillus species from cleaning workers' exposure in nursing homes
ผู้แต่ง: Lu R.
Tendal K.
Frederiksen M.W.
Uhrbrand K.
Li Y.
Madsen A.M.
Keywords: Aspergillus
Cleaning
Cytotoxicity
Hospitals
Nursing
Fungal isolates
Fungal species
Geometric mean
Health effects
In-vitro assays
Personal exposures
Risk evaluation
Workers' exposures
Air cleaners
fungus
health impact
occupational exposure
risk assessment
toxicity
workplace
article
Aspergillus
cleaning
cytotoxicity
dose response
fungus spore
human
human cell
low drug dose
matrix assisted laser desorption ionization time of flight mass spectrometry
Niger
nonhuman
nursing home
occupational health
Penicillium
risk assessment
worker
Aspergillus
environmental monitoring
fungus
indoor air pollution
microbiology
nursing home
Aspergillus
Aspergillus candidus
Aspergillus fumigatus
Aspergillus niger
Fungi
Penicillium
Penicillium italicum
Air Microbiology
Air Pollution, Indoor
Aspergillus
Environmental Monitoring
Fungi
Humans
Niger
Nursing Homes
Penicillium
วันที่เผยแพร่: 2020
บทคัดย่อ: Penicillium and Aspergillus are among the dominant genera of fungi in many environments. Exposure to these fungi may cause inflammation-related health effects, however the knowledge about this at species level is limited. The aim of this study was to obtain knowledge about cleaning workers' exposure to fungi and to investigate the total inflammatory potential (TIP) and the cytotoxic potential of fungal species. The fungi were obtained from the personal exposure of cleaning workers' in five nursing homes. In total 271 fungal isolates were identified using MALDI-TOF MS. The TIP and cytotoxic potential were determined for 30 different fungal isolates covering 17 species in an in vitro assay by exposing HL-60 cells to the fungal spores of each isolate. The geometric mean exposure of the cleaning workers was 351 CFU fungi/m3 air. We showed that the TIP and cytotoxicity varied among both species and isolates. At the two lowest doses, there was a positive relationship between spore concentration and TIP. The species with highest TIPs were A. candidus and P. italicum, while the most cytotoxic ones were A. niger and A. fumigatus. There was no obvious relationship between the TIP of an isolate and its cytotoxicity. The results of this study provide a better understanding of the inflammatory potential and cytotoxicity of different environmental fungal species and contribute to the risk evaluation of exposure to different Penicillium and Aspergillus species. © 2020 Elsevier B.V.
URI: https://ir.swu.ac.th/jspui/handle/123456789/11905
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083303299&doi=10.1016%2fj.scitotenv.2020.138231&partnerID=40&md5=fb914b0174ec3f6ea70c00cfaf9bf602
ISSN: 489697
Appears in Collections:Scopus 1983-2021

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