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https://ir.swu.ac.th/jspui/handle/123456789/13912| Title: | Combating Helicobacter pylori infections with mucoadhesive nanoparticles loaded with Garcinia mangostana extract |
| Authors: | Pan-In P. Tachapruetinun A. Chaichanawongsaroj N. Banlunara W. Suksamrarn S. Wanichwecharungruang S. |
| Keywords: | alpha mangostin amoxicillin antiinfective agent clarithromycin Garcinia mangostana extract metronidazole nanocarrier plant extract unclassified drug adhesin drug carrier mangostin nanoparticle plant extract xanthone derivative acidity animal cell animal experiment animal model animal tissue antiadhesion activity antibacterial activity article bacterial strain bacterium detection column chromatography controlled study differential scanning calorimetry drug activity drug delivery system drug isolation drug stability Garcinia mangostana Helicobacter infection Helicobacter pylori high performance liquid chromatography human human cell in vitro study in vivo study minimum inhibitory concentration mouse mucoadhesion nanoencapsulation nonhuman priority journal scanning electron microscope scanning electron microscopy spectrophotometer stomach mucosa sustained drug release animal C57BL mouse cell line chemistry drug effects Garcinia mangostana Helicobacter Infections microbiology physiology stomach Adhesins, Bacterial Animals Cell Line Drug Carriers Garcinia mangostana Helicobacter Infections Helicobacter pylori Humans Mice Mice, Inbred C57BL Nanoparticles Plant Extracts Stomach Xanthones |
| Issue Date: | 2014 |
| Abstract: | Aim: To combat the resistance of Helicobacter pylori to antibiotics through the use of Garcinia mangostana extract (GME) in the form that can be localized at stomach mucosa. Materials & methods: GME and its major active component, α-mangostin, are encapsulated into the moderately acid stable mucoadhesive nanocarriers, and tested for anti-H. pylori and antiadhesion activities in vitro and their ability to eradicate H. pylori in infected mice. Results: The two in vitro activities are observed and are enhanced when the materials are encapsulated into nanocarriers. Preliminary in vivo tests revealed the ability to combat H. pylori in mice following oral administration of the encapsulated GME, but not the unencapsulated GME. Conclusion: Nanoencapsulated GME is a potential anti-H. pylori agent. Original submitted 10 August 2012; Revised submitted 9 December 2012; Published online 3 June 201. © 2014 Future Medicine Ltd. |
| URI: | https://ir.swu.ac.th/jspui/handle/123456789/13912 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84898936119&doi=10.2217%2fnnm.13.30&partnerID=40&md5=0bdd3bda21deea7f14f0491906eb356a |
| ISSN: | 17435889 |
| Appears in Collections: | Scopus 1983-2021 |
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