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Synthesis and structural characterization of 1-[2-(5-Nitro-1H-indol-2-yl) phenyl]methylpyridinium chloride

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dc.contributor.authorBremner J.B.
dc.contributor.authorSamosorn S.
dc.contributor.authorSkelton B.W.
dc.contributor.authorWhite A.H.
dc.date.accessioned2021-04-05T03:35:04Z
dc.date.available2021-04-05T03:35:04Z
dc.date.issued2011
dc.date.issuedBE2554
dc.description.abstractIn the course of studies on hybrid antibacterials incorporating 2-aryl-5-nitro-1Hindole moieties as potential bacterial NorA efflux pump inhibitors, the compound 1-[2-(5-nitro-1H-indol-2-yl)phenyl]methylpyridinium chloride (2) was synthesized and structurally characterized. This pyridinium chloride salt crystallized in the monoclinic space group P21/c with the following unit cell dimensions: a 10.274(3) Å, b 13.101(4) Å, c 13.439(4) Å, β 107.702(7)°, V 1723.2(9) Å 3, Z (f.u.) = 4; R1 = 0.048, and wR2 = 0.13. Of interest in the single crystal X-ray structure is the (intramolecular) disposition of the pyridinium plane over the indole heterocyclic residue [interplanar dihedral angle 17.91(4)°]. © 2011 by The Authors.
dc.format.mimetypeapplication/pdf
dc.identifier.citationMolecules. Vol 16, No.9 (2011), p.7627-7633
dc.identifier.doi10.3390/molecules16097627
dc.identifier.issn14203049
dc.identifier.other2-s2.0-80053280302
dc.identifier.urihttps://hdl.handle.net/20.500.14740/7250
dc.rights.holderScopus
dc.subject.otherAntiinfective agent
dc.subject.otherBacterial protein
dc.subject.otherIndole derivative
dc.subject.otherMultidrug resistance protein
dc.subject.otherNorA protein, Staphylococcus
dc.subject.otherPyridinium derivative
dc.subject.otherArticle
dc.subject.otherChemistry
dc.subject.otherConformation
dc.subject.otherDrug antagonism
dc.subject.otherDrug effect
dc.subject.otherMetabolism
dc.subject.otherStaphylococcus aureus
dc.subject.otherSynthesis
dc.subject.otherX ray crystallography
dc.subject.otherAnti-Bacterial Agents
dc.subject.otherBacterial Proteins
dc.subject.otherCrystallography
dc.subject.otherIndoles
dc.subject.otherMolecular Conformation
dc.subject.otherMultidrug Resistance-Associated Proteins
dc.subject.otherPyridinium Compounds
dc.subject.otherStaphylococcus aureus
dc.titleSynthesis and structural characterization of 1-[2-(5-Nitro-1H-indol-2-yl) phenyl]methylpyridinium chloride
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-80053280302&doi=10.3390%2fmolecules16097627&partnerID=40&md5=d2edd2dd5e107f5ccb61399edecf489a

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