Publication:
Barakol, a natural anxiolytic inhibits striatal dopamine release but not uptake in vitro

2
0

Issued Date

1997

Resource Type

Article

File Type

application/pdf

ISSN

142999

DOI

10.1016/S0014-2999(96)00850-3

Other identifier(s)

2-s2.0-0031032513

Rights Holder(s)

Scopus

Bibliographic Citation

European Journal of Pharmacology. Vol 319, (1997), p.157-164

Suggested Citation

Thongsaard W., Pongsakorn S., Sudsuang R., Bennett G.W., Kendall D.A., Marsden C.A. Barakol, a natural anxiolytic inhibits striatal dopamine release but not uptake in vitro. European Journal of Pharmacology. Vol 319, (1997), p.157-164. doi:10.1016/S0014-2999(96)00850-3 Retrieved from: https://hdl.handle.net/20.500.14740/7309

Title

Barakol, a natural anxiolytic inhibits striatal dopamine release but not uptake in vitro

Author(s)

Thongsaard W.
 Pongsakorn S.
 Sudsuang R.
 Bennett G.W.
 Kendall D.A.
 Marsden C.A.

Abstract

The present study investigated the effects of barakol on the in vitro release of endogenous and radiolabelled dopamine from rat striatal slices in comparison with the dopamine receptor agonist, quinelorane dihydrochloride (1 μM) and pergolide methanesulfonate (100 μM), and the dopamine receptor antagonist, S(-)-eticlopride hydrochloride (10 μM) using a semi-superfusion method and high-performance liquid chromatography with electrochemical detector measurement of endogenous dopamine. Barakol (1, 10 and 100 μM) reduced K+-stimulated endogenous dopamine release as did the dopamine D2 receptor agonists but had no effect on [3H]dopamine release. The inhibition of barakol (10 μM) on K+-stimulated endogenous dopamine release was antagonised by a dopamine D2 receptor antagonist, eticlopride. Barakol (0.1 nM-10 μM) had no effect on [3H]dopamine uptake except at the highest concentration (100 μM) when inhibition was observed. The results indicate that barakol might act as a dopamine agonist to inhibit endogenous dopamine release without a change in dopamine uptake.

Subject(s)

Barakol
 Dopamine receptor stimulating agent
 Eticlopride
 Pergolide mesilate
 Quinelorane
 Unclassified drug
 Animal tissue
 Article
 Brain slice
 Controlled study
 Dopamine release
 Dopamine uptake
 Male
 Nonhuman
 Priority journal
 Rat
 Animals
 Anti-Anxiety Agents
 Benzopyrans
 Calcium
 Cassia
 Chromatography, High Pressure Liquid
 Dopamine
 Dopamine Agonists
 Electrochemistry
 Male
 Neostriatum
 Pergolide
 Phenalenes
 Plant Extracts
 Plants, Medicinal
 Potassium
 Rats
 Receptors, Dopamine D2

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URI

https://hdl.handle.net/20.500.14740/7309

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Scopus: Year 1983-2021

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