Publication:
Development of mannosylated liposomes using synthesized N-octadecyl-D-mannopyranosylamine to enhance gastrointestinal permeability for protein delivery

Simple item page
dc.contributor.authorWitoonsaridsilp W.
dc.contributor.authorPaeratakul O.
dc.contributor.authorPanyarachun B.
dc.contributor.authorSarisuta N.
dc.date.accessioned2021-04-05T03:34:12Z
dc.date.available2021-04-05T03:34:12Z
dc.date.issued2012
dc.date.issuedBE2555
dc.description.abstractThe lysozyme (LZ)-entrapped mannosylated liposomes were prepared in this study by the use of N-octadecyl-d-mannopyranosylamine (SAMAN), which had been synthesized in-house and confirmed by characterization with FTIR and NMR. The reactant residues of synthesized SAMAN were found to be less than 1%. The mean sizes, zeta potentials, drug entrapment efficiencies, and loading capacities of all liposomal formulations were in the ranges of 234.7 to 431.0 nm, -10.97 to -25.80 mV, 7.52 to 14.10%, and 1.44 to 2.77%, respectively. The permeability of mannosylated LZ liposomes across Caco-2 cell monolayers was significantly enhanced to about 2.5- and 7-folds over those of conventional liposomes and solution, respectively, which might be due to the role of mannose receptor or mannose-binding protein on the intestinal enterocytes. © 2012 American Association of Pharmaceutical Scientists.
dc.format.mimetypeapplication/pdf
dc.identifier.citationAAPS PharmSciTech. Vol 13, No.2 (2012), p.699-706
dc.identifier.doi10.1208/s12249-012-9788-1
dc.identifier.issn15309932
dc.identifier.other2-s2.0-84862904378
dc.identifier.urihttps://hdl.handle.net/20.500.14740/7040
dc.rights.holderมหาวิทยาลัยศรีนครินทรวิโรฒ
dc.subject.otherLigand
dc.subject.otherLiposome
dc.subject.otherMannose
dc.subject.otherMannose binding protein
dc.subject.otherMannose receptor
dc.subject.otherMannosylated liposome
dc.subject.otherN octadecyl d mannopyranosylamine
dc.subject.otherUnclassified drug
dc.subject.otherArticle
dc.subject.otherCell strain CACO 2
dc.subject.otherCell surface
dc.subject.otherCrystal structure
dc.subject.otherDrug adsorption
dc.subject.otherDrug formulation
dc.subject.otherDrug penetration
dc.subject.otherHuman
dc.subject.otherHuman cell
dc.subject.otherInfrared spectroscopy
dc.subject.otherIntestine cell
dc.subject.otherIntestine mucosa permeability
dc.subject.otherNuclear magnetic resonance
dc.subject.otherParticle size
dc.subject.otherPhysical chemistry
dc.subject.otherPriority journal
dc.subject.otherProtein transport
dc.subject.otherSynthesis
dc.subject.otherZeta potential
dc.subject.otherAmino Sugars
dc.subject.otherBiological Transport
dc.subject.otherCaco-2 Cells
dc.subject.otherChemistry, Pharmaceutical
dc.subject.otherHumans
dc.subject.otherIntestinal Absorption
dc.subject.otherIntestinal Mucosa
dc.subject.otherKinetics
dc.subject.otherLectins, C-Type
dc.subject.otherLipids
dc.subject.otherMagnetic Resonance Spectroscopy
dc.subject.otherMannose-Binding Lectin
dc.subject.otherMannose-Binding Lectins
dc.subject.otherMuramidase
dc.subject.otherNanoparticles
dc.subject.otherParticle Size
dc.subject.otherPermeability
dc.subject.otherReceptors, Cell Surface
dc.subject.otherSpectroscopy, Fourier Transform Infrared
dc.subject.otherTechnology, Pharmaceutical
dc.titleDevelopment of mannosylated liposomes using synthesized N-octadecyl-D-mannopyranosylamine to enhance gastrointestinal permeability for protein delivery
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84862904378&doi=10.1208%2fs12249-012-9788-1&partnerID=40&md5=874ac5247e15378814d0b1fdb0289395

Files

Collections

Scopus: Year 1983-2021