Publication: Association Between Staphylococcus Aureus Colonization and Pediatric Atopic Dermatitis: A Systematic Review and Meta-Analysis
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Issued Date
2023-11-01
Resource Type
ISSN
00195154
eISSN
19983611
Scopus ID
2-s2.0-85193482117
Journal Title
Indian Journal of Dermatology
Volume
68
Issue
6
Start Page
619
End Page
627
Rights Holder(s)
SCOPUS
Bibliographic Citation
Indian Journal of Dermatology Vol.68 No.6 (2023) , 619-627
Suggested Citation
Sangaphunchai P., Kritsanaviparkporn C., Treesirichod A. Association Between Staphylococcus Aureus Colonization and Pediatric Atopic Dermatitis: A Systematic Review and Meta-Analysis. Indian Journal of Dermatology Vol.68 No.6 (2023) , 619-627. 627. doi:10.4103/ijd.ijd_453_22 Retrieved from: https://hdl.handle.net/20.500.14740/20248
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Abstract
Background: Atopic dermatitis is a chronic inflammatory skin condition common in early childhood. Acute exacerbation is frequently associated with Staphylococcus aureus colonization. Aims and Objectives: This study aims to explore the relationship between S. aureus skin and nasal colonization with pediatric atopic dermatitis. Methods: A systematic review and meta-analysis were conducted by comparing atopic dermatitis patients aged ≤18 years and nondiseased controls. A random-effects model was used to obtain the pooled prevalence and odds ratio of S. aureus colonization at eczematous skin, nonlesional skin, and nasal cavity. Subgroup analyses for colonization with methicillin-resistant S. aureus were also evaluated. Results: A total of 2,670 cases and 1,224 controls from 26 studies were included in the meta-analysis. S. aureus colonization at eczematous skin and nasal cavity is significantly higher in atopic dermatitis compared to control with odds ratios of 10.55 (95% confidence interval [CI]; 4.85-22.92, P < .001) and 2.38 (nasal cavity; 95% CI; 1.46-3.90, P < .001), respectively. The pooled prevalence of skin and nasal colonization were 55.0% (eczematous skin; 95% CI; 38.3-71.7), 23.3% (nonlesional skin; 95% CI; 12.6-33.9), and 56.3% (95% CI; 43.2-69.4), respectively. Methicillin-resistant S. aureus strain was obtained from the nares and eczematous skin with rates of 11.6% (95% CI; 6.5-16.7) and 8.5% (95% CI; 4.3-12.8), respectively. Conclusion: Children with atopic dermatitis are more prone to skin and nasal colonization by S. aureus compared to nondiseased individuals.