Publication:
Biotransformation of α-mangostin by Colletotrichum sp. MT02 and Phomopsis euphorbiae K12

Simple item page
dc.contributor.authorArunrattiyakorn P.
dc.contributor.authorSuwannasai N.
dc.contributor.authorAree T.
dc.contributor.authorKanokmedhakul S.
dc.contributor.authorIto H.
dc.contributor.authorKanzaki H.
dc.date.accessioned2021-04-05T03:32:26Z
dc.date.available2021-04-05T03:32:26Z
dc.date.issued2014
dc.date.issuedBE2557
dc.description.abstractThe microbial transformation of the major mangosteen pericarp xanthone, α-mangostin (1) by the endophytic fungi Colletotrichum sp. MT02 and Phomopsis euphorbiae K12 resulted in the production of the five metabolites 2-6. Biotransformation with Colletotrichum sp. MT02 converted 1 into 17,18-dihydroxymangostanin (2) and cyclomangostanin (3), while incubation with P. euphorbiae K12 gave 12,13,20-trihydroxymangostin (4), 12,13,19- trihydroxymangostin (5), and 20-hydroxymangostanin (6) as transformation products. The structures of these metabolites were elucidated via spectroscopic analyses, and for compound 3, the structure was confirmed by X-ray crystallographic analysis. All metabolites are new, and metabolite 3 possessed an unusual structure of bis-ring fused xanthene in nature. In addition, substrate and all products were evaluated for the antimycobacterial activity against Mycobacterium tuberculosis as well as the cytotoxicity against breast cancer (MCF-7) cell lines. © 2014 Elsevier B.V.
dc.format.mimetypeapplication/pdf
dc.identifier.citationJournal of Molecular Catalysis B: Enzymatic. Vol 102, (2014), p.174-179
dc.identifier.doi10.1016/j.molcatb.2014.02.010
dc.identifier.issn13811177
dc.identifier.other2-s2.0-84896280271
dc.identifier.urihttps://hdl.handle.net/20.500.14740/6309
dc.rights.holderScopus
dc.subject.otherBioconversion
dc.subject.otherBiomolecules
dc.subject.otherCell culture
dc.subject.otherSpectroscopic analysis
dc.subject.otherX ray crystallography
dc.subject.otherAntimycobacterial activity
dc.subject.otherBiotransformation
dc.subject.otherColletotrichum sp
dc.subject.otherMicrobial transformation
dc.subject.otherMycobacterium tuberculosis
dc.subject.otherPhomopsis
dc.subject.otherPrenylated xanthone
dc.subject.otherX-ray crystallographic analysis
dc.subject.otherMetabolites
dc.subject.other12,13,19 trihydroxymangostin
dc.subject.other12,13,20 trihydroxymangostin
dc.subject.other17,18 dihydroxymangostanin
dc.subject.other20 hydroxymangostanin
dc.subject.otherAlpha mangostin
dc.subject.otherAntiinfective agent
dc.subject.otherCyclomangostanin
dc.subject.otherDoxorubicin
dc.subject.otherTamoxifen
dc.subject.otherUnclassified drug
dc.subject.otherXanthone derivative
dc.subject.otherAntimicrobial activity
dc.subject.otherArticle
dc.subject.otherBiotransformation
dc.subject.otherCarbon nuclear magnetic resonance
dc.subject.otherColletotrichum
dc.subject.otherCytotoxicity
dc.subject.otherEnzyme structure
dc.subject.otherEnzyme substrate
dc.subject.otherEnzyme synthesis
dc.subject.otherFungal strain
dc.subject.otherFungus
dc.subject.otherFungus isolation
dc.subject.otherGarcinia mangostana
dc.subject.otherIC 50
dc.subject.otherIncubation time
dc.subject.otherNonhuman
dc.subject.otherNucleotide sequence
dc.subject.otherOlive tree
dc.subject.otherPhomopsis euphorbiae
dc.subject.otherProton nuclear magnetic resonance
dc.subject.otherX ray crystallography
dc.titleBiotransformation of α-mangostin by Colletotrichum sp. MT02 and Phomopsis euphorbiae K12
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84896280271&doi=10.1016%2fj.molcatb.2014.02.010&partnerID=40&md5=a30cd03964204fad2d898a40f5a87983

Files

Collections

Scopus: Year 1983-2021