Publication:
Optimization and evaluation of thermoresponsive diclofenac sodium ophthalmic in situ gels

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Issued Date

2011

Resource Type

Article

File Type

application/pdf

ISSN

3785173

DOI

10.1016/j.ijpharm.2011.03.054

Other identifier(s)

2-s2.0-79955964137

Rights Holder(s)

Scopus

Bibliographic Citation

International Journal of Pharmaceutics. Vol 411, (2011), p.128-135

Suggested Citation

Asasutjarit R., Thanasanchokpibull S., Fuongfuchat A., Veeranondha S. Optimization and evaluation of thermoresponsive diclofenac sodium ophthalmic in situ gels. International Journal of Pharmaceutics. Vol 411, (2011), p.128-135. doi:10.1016/j.ijpharm.2011.03.054 Retrieved from: https://hdl.handle.net/20.500.14740/7304

Title

Optimization and evaluation of thermoresponsive diclofenac sodium ophthalmic in situ gels

Author(s)

Asasutjarit R.
 Thanasanchokpibull S.
 Fuongfuchat A.
 Veeranondha S.

Abstract

This work was conducted to optimize and evaluate Pluronic F127-based thermoresponsive diclofenac sodium ophthalmic in situ gels (DS in situ gel). They were prepared by cold method and investigated their physicochemical properties i.e., pH, flow ability, sol-gel transition temperature, gelling capacity and rheological properties. An optimized formulation was selected and investigated its physicochemical properties before and after autoclaving, eye irritation potency in SIRC cells and rabbits. In vivo ophthalmic absorption was performed in rabbits. It was found that physicochemical properties of DS in situ gels were affected by formulation compositions. Increment of Pluronic F127 content decreased sol-gel transition temperature of the products while increase in Pluronic F68 concentration tended to increase sol-gel transition temperature. In this study, Carbopol 940 did not affect sol-gel transition temperature but it affected transparency, pH, and gelling capacity of the products. The optimized formulation exhibited sol-gel transition at 32.6 ± 1.1°C with pseudoplastic flow behavior. It was lost diclofenac sodium content during autoclaving. However, it was accepted as safe for ophthalmic use and could increase diclofenac sodium bioavailability in aqueous humor significantly. In conclusion, the optimized DS in situ gel had potential for using as an alternative to the conventional diclofenac sodium eye drop. However, autoclaving was not a suitable sterilization method for this product. © 2011 Elsevier B.V. All rights reserved.

Subject(s)

Benzalkonium chloride
 Carbopol 940
 Diclofenac
 Poloxamer
 Animal cell
 Animal experiment
 Aqueous humor
 Article
 Autoclave
 Controlled study
 Drug absorption
 Drug bioavailability
 Drug formulation
 Eye irritation
 Female
 Flow kinetics
 Gel
 In vivo study
 Male
 Nonhuman
 PH
 Priority journal
 Rabbit
 Shear flow
 Transition temperature
 Acrylic Resins
 Administration, Ophthalmic
 Animals
 Anti-Inflammatory Agents, Non-Steroidal
 Aqueous Humor
 Diclofenac
 Drug Administration Routes
 Drug Compounding
 Drug Delivery Systems
 Excipients
 Eye
 Gels
 Hot Temperature
 Male
 Ophthalmic Solutions
 Phase Transition
 Physicochemical Phenomena
 Poloxamer
 Rabbits
 Sterilization
 Transition Temperature

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URI

https://hdl.handle.net/20.500.14740/7304

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Scopus: Year 1983-2021

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