Publication: Cystatin C as a novel predictor of preterm labor in severe preeclampsia
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Issued Date
2018
Resource Type
File Type
application/pdf
ISSN
22119132
Other identifier(s)
2-s2.0-85059210576
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
Kidney Research and Clinical Practice. Vol 37, No.4 (2018), p.1-9
Suggested Citation
Wattanavaekin K., Kitporntheranunt M., Kreepala C. Cystatin C as a novel predictor of preterm labor in severe preeclampsia. Kidney Research and Clinical Practice. Vol 37, No.4 (2018), p.1-9. doi:10.23876/j.krcp.18.0080 Retrieved from: https://hdl.handle.net/20.500.14740/5766
Author(s)
Abstract
Background: The most common cause of acute kidney injury (AKI) in pregnancy is preeclampsia. Serum cystatin C (CysC) is a potential biomarker of early kidney damage as its levels are not disturbed by volume status changes in pregnancy, and serum CysC levels could serve as a replacement for conventionally used creatinine. In this study, we investigated the serum levels of CysC in severe preeclampsia cases and the associations between CysC levels and poor obstetric outcomes. Methods: Our cohort included severe preeclampsia patients with a normal serum creatinine level. Creatinine was measured to calculate estimated glomerular filtration rate (eGFR) based on the Cockcroft and Gault, Modification of Diet in Renal Disease Study (MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations, while CysC was measured to calculated eGFR based on a CysC-based equation. We then evaluated the correlations between serum CysC level, eGFR, and obstetric outcomes. Results: Twenty-six patients were evaluated of which 38.5% delivered preterm and 30.8% had low-birth weight babies. Unlike creatinine-based eGFR and CysC-based eGFR, serum CysC demonstrate significant negative correlation with gestational age. Receiver operating characteristic curve analysis indicated that serum CysC is a potential biomarker of preterm delivery with a cut-off serum level of 1.48 mg/L with 80% sensitivity and 75% specificity. Conclusion: GFR estimation using CysC is likely to be inaccurate in pregnancy. However, we found a significant correlation between preterm delivery and serum CysC level. Our results suggest that serum CysC level has the potential to predict preterm delivery in severe preeclampsia patients. © 2018 by The Korean Society of Nephrology.
Subject(s)
Creatinine
Cystatin C
Adult
Area under the curve
Article
Chronic Kidney Disease Epidemiology Collaboration equation
Clinical article
Cockcroft and Gault equation
Cohort analysis
Creatinine blood level
Diagnostic test accuracy study
Disease association
Disease severity
Estimated glomerular filtration rate
Female
Gestational age
Human
Incidence
Low birth weight
Mathematical parameters
Measurement accuracy
Modification of Diet in Renal Disease Study equation
Prediction
Predictor variable
Preeclampsia
Pregnancy outcome
Premature labor
Priority journal
Prospective study
Protein blood level
Receiver operating characteristic
Risk
Sensitivity and specificity
Cystatin C
Adult
Area under the curve
Article
Chronic Kidney Disease Epidemiology Collaboration equation
Clinical article
Cockcroft and Gault equation
Cohort analysis
Creatinine blood level
Diagnostic test accuracy study
Disease association
Disease severity
Estimated glomerular filtration rate
Female
Gestational age
Human
Incidence
Low birth weight
Mathematical parameters
Measurement accuracy
Modification of Diet in Renal Disease Study equation
Prediction
Predictor variable
Preeclampsia
Pregnancy outcome
Premature labor
Priority journal
Prospective study
Protein blood level
Receiver operating characteristic
Risk
Sensitivity and specificity