Publication: CT findings of native lung after single lung transplantation in patients with idiopathic pulmonary fibrosis: Long-term outcomes
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Issued Date
2016
Resource Type
File Type
application/pdf
ISSN
19405901
Other identifier(s)
2-s2.0-84977079182
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
International Journal of Clinical and Experimental Medicine. Vol 9, No.6 (2016), p.9087-9093
Suggested Citation
Wu X., Burivong W., Ma D., Edelman J.D., Richardson M.L., Chen H., Stern E.J. CT findings of native lung after single lung transplantation in patients with idiopathic pulmonary fibrosis: Long-term outcomes. International Journal of Clinical and Experimental Medicine. Vol 9, No.6 (2016), p.9087-9093. Retrieved from: https://hdl.handle.net/20.500.14740/5341
Abstract
To evaluate the progression of native lung fibrosis on thin-section computed tomography (CT) scans from patients with IPF after SLT, we retrospectively studied thin-section CT findings of the patients who survived more than 3 years. Three radiologists independently reviewed serial CT images from 12 patients who underwent SLT for IPF. Initial CT scans were performed up to 7 months before SLT or ≤12 months after SLT, and follow-up CT scan were performed >36 months after SLT. CT measurements of the total lung volume were performed on native lungs. CT scores were evaluated for native lung findings for each thin-section CT, including the fibrosis score (FS), ground-glass opacity score (GGS), and traction bronchiectasis score (TBS). Twelve patients survived 43-110 months after SLT. In the native lung, the FS and TBS values were positively correlated with time. Rates of increase in the FS and TBS values were 0.300/year and 0.147/year, respectively. The GGS showed a slight negative correlation with the lung volume from the CT reconstruction. Rates of decrease of the GGS and lung volume measurements were 0.307/year and 5.47%/year, respectively. The results show that despite more powerful immunosuppression, fibrosis of native lung continues to progress in patients who receive SLT for IPF. © 2016, E-Century Publishing Corporation. All rights reserved.
Subject(s)
Acetylcysteine
Azathioprine
Gamma interferon
Mycophenolate mofetil
Prednisone
Tacrolimus
Adult
Aged
Article
Bronchiectasis
Bronchodilatation
Clinical article
Computer assisted tomography
Disease course
Disease specific survival
Female
Fibrosing alveolitis
Follow up
Human
Immunosuppressive treatment
Lung fibrosis
Lung transplantation
Lung volume
Male
Middle aged
Pleura cavity
Retrospective study
Scoring system
Azathioprine
Gamma interferon
Mycophenolate mofetil
Prednisone
Tacrolimus
Adult
Aged
Article
Bronchiectasis
Bronchodilatation
Clinical article
Computer assisted tomography
Disease course
Disease specific survival
Female
Fibrosing alveolitis
Follow up
Human
Immunosuppressive treatment
Lung fibrosis
Lung transplantation
Lung volume
Male
Middle aged
Pleura cavity
Retrospective study
Scoring system