Publication: Antiproliferative polyketides from fungus Xylaria cf. Longipes SWUF08-81 in different culture media
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Issued Date
2024-12-01
Resource Type
ISSN
21922195
eISSN
21922209
Scopus ID
2-s2.0-85181502991
Journal Title
Natural Products and Bioprospecting
Volume
14
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Natural Products and Bioprospecting Vol.14 No.1 (2024)
Suggested Citation
Sresuksai K., Sawadsitang S., Jantaharn P., Noppawan P., Churat A., Suwannasai N., Mongkolthanaruk W., Senawong T., Tontapha S., Moontragoon P., Amornkitbamrung V., Mccloskey S. Antiproliferative polyketides from fungus Xylaria cf. Longipes SWUF08-81 in different culture media. Natural Products and Bioprospecting Vol.14 No.1 (2024). doi:10.1007/s13659-023-00427-7 Retrieved from: https://hdl.handle.net/20.500.14740/20857
Corresponding Author(s)
Other Contributor(s)
Abstract
Bioactive compounds from the wood-decay fungus Xylaria cf. longipes SWUF08-81, cultivated in three different culture media (GM, YM and PDB), were isolated. Their structures and stereochemistry were deduced from spectroscopic and MS data analysis, together with quantum chemical calculations of 13C NMR chemical shifts and electronic circular dichroism (ECD) spectra. Five undescribed polyketides including dibenzofuran (1), mellein (2), dihydroisocoumarin (15), and two pyrans (16, 17), together with twenty-three compounds were determined. Compounds 18 and 20 were significantly toxic against cancer cell lines (HCT116, HT29, MCF-7 and HeLa) based on the MTT assay. Quantification by HPLC showed that 18 was produced three-fold higher in the broth of PDB than YM. These studies showed that the production of different compounds were primarily dependent on nutrition sources and it has given a starting point for the growth optimization conditions for the scaling up of bioactive compounds production. Graphical Abstract: [Figure not available: see fulltext.]