Publication: The Development of Sweet Basil Essential Oils Nanoemulsion for Scototaxis Behaviors in Zebrafish
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Issued Date
2024-07-01
Resource Type
eISSN
29850290
Scopus ID
2-s2.0-105005601845
Journal Title
Science Essence Journal
Volume
40
Issue
2
Start Page
87
End Page
97
Rights Holder(s)
SCOPUS
Bibliographic Citation
Science Essence Journal Vol.40 No.2 (2024) , 87-97
Suggested Citation
Khamaon Y., Raksat N., Atiratana T., Ruenthoy N., Praphairaksit N. The Development of Sweet Basil Essential Oils Nanoemulsion for Scototaxis Behaviors in Zebrafish. Science Essence Journal Vol.40 No.2 (2024) , 87-97. 97. Retrieved from: https://hdl.handle.net/20.500.14740/21040
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Abstract
Sweet basil is an herb known for its essential oils, widely used in the food and fragrance industries. This essential oil contains a compound with calming properties; however, only a few preclinical studies show the anxiolytic effect of sweet basil essential oil. This study aimed to test the anxiety-related effect of sweet basil essential oil in zebrafish and develop nanoemulsion to enhance its therapeutic effects. Gas chromatography-mass spectrometry (GC-MS) identifies the anxiolytic compounds of sweet basil essential oil including estragole (100%) and linalool (25.52%). A nanoemulsion of sweet basil oil was developed and measured physical properties by zetasizer. We found that nanoemulsion had particles size of 52. 96±14. 69 nm and a dispersion value of 0.25±0.01. The scototaxis behavior test of zebrafish was performed, and the anxiety-related compounds (ethanol and fluoxetine) were compared with sweet basil essential oil and nanoemulsion. The anxiolytic effects of sweet basil essential oil and its nanoemulsion were found in zebrafish. These findings indicate that sweet basil essential oil, particularly as a nanoemulsion, has potential as an alternative treatment for anxiety-related behavior.