Publication:
Efficacy and safety of a novel water-soluble herbal patch for acne vulgaris treatment: A randomized, assessor-blinds controlled, intra-individual split-face comparative study

4
0

Issued Date

2021

Resource Type

Article

Language

eng

File Type

application/pdf

ISSN

13960296

DOI

10.1111/dth.14925

Other identifier(s)

2-s2.0-85102365061

Rights Holder(s)

Scopus

Bibliographic Citation

Dermatologic Therapy. Vol 34, No.3 (2021)

Suggested Citation

Jaturapisanukul K., Udompataikul M., Kanokrungsee S., Rojhirunsakool S., Kamanamool N., Rachpirom M., Puttarak P. Efficacy and safety of a novel water-soluble herbal patch for acne vulgaris treatment: A randomized, assessor-blinds controlled, intra-individual split-face comparative study. Dermatologic Therapy. Vol 34, No.3 (2021). doi:10.1111/dth.14925 Retrieved from: https://hdl.handle.net/20.500.14740/7816

Title

Efficacy and safety of a novel water-soluble herbal patch for acne vulgaris treatment: A randomized, assessor-blinds controlled, intra-individual split-face comparative study

Author(s)

Jaturapisanukul K.
 Udompataikul M.
 Kanokrungsee S.
 Rojhirunsakool S.
 Kamanamool N.
 Rachpirom M.
 Puttarak P.

Abstract

Acne vulgaris is a chronic inflammatory skin disease. Antibiotics, particularly clindamycin and erythromycin, are used for the treatment of acne vulgaris. However, emerging antibiotic-resistant strains have been an important problem. This study aims to evaluate the efficiency and safety of a novel water-soluble herbal acne patch (WHAP) compared with the hydrocolloid acne patch (HAP) in mild to moderate inflammatory acne patients. The randomized, assessor-blind controlled, intra-individual split-face study was performed on 49 acne patients. The clinical outcomes were evaluated on day 2, 4, 7, 9, and 11 of treatment. It was shown that the median time to resolution of the inflammatory acne treated with WHAP was shorter than HAP with a statistically significant difference (WHAP was 4 days, whereas HAP was 6 days) (P value <.001). Moreover, WHAP had a more significant decrease in the rate of inflammatory diameter, erythema scores (by clinical and colorimetry), and a more increase in the rate of lightness scores (by colorimetry) than HAP (P value <.05). No adverse effects were reported in both groups. It is safe to use WHAP as an alternative treatment for inflammatory acne. © 2021 Wiley Periodicals LLC.

Subject(s)

Alginic acid
 Alpha tocopherol
 Ascorbic acid
 Centella asiatica extract
 Cornus officinalis extract
 Emblica officinalis extract
 Glycerol
 Antiinfective agent
 Clindamycin
 Water
 Acne
 Acne vulgaris
 Adult
 Article
 Clinical article
 Clinical outcome
 Colorimetry
 Comedo
 Comparative study
 Controlled study
 Device safety
 Erythema
 Female
 Human
 Inflammation
 Male
 Median survival time
 Papule
 Patch test
 Patient satisfaction
 Physical examination
 Randomized controlled trial
 Young adult
 Acne vulgaris
 Double blind procedure
 Skin
 Treatment outcome
 Acne Vulgaris
 Anti-Bacterial Agents
 Clindamycin
 Double-Blind Method
 Humans
 Skin
 Treatment Outcome
 Water

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URI

https://hdl.handle.net/20.500.14740/7816

Collections

Scopus: Year 1983-2021

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