Publication: Terrein inhibits aggressive phenotype of A549 human lung cancer cell through suppression of HIF-1α
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Issued Date
2021
Resource Type
Language
eng
File Type
application/pdf
ISSN
16863933
Other identifier(s)
2-s2.0-85107692620
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
Walailak Journal of Science and Technology. Vol 18, No.11 (2021)
Suggested Citation
Buachan P., Namsa-Aid M., Tanechpongtamb W. Terrein inhibits aggressive phenotype of A549 human lung cancer cell through suppression of HIF-1α. Walailak Journal of Science and Technology. Vol 18, No.11 (2021). doi:10.48048/WJST.2021.10605 Retrieved from: https://hdl.handle.net/20.500.14740/8035
Author(s)
Abstract
Terrein is a fungal metabolite that has already been reported with anticancer properties. However, the effect on the aggressive phenotype of cancer cells has not been elucidated yet. In the present study, the cytotoxicity of terrein was first determined against lung cancer cells (A549) model and compared with several normal cell lines (Vero, L6, and H9C2 cells). The data demonstrated that terrein had a specific effect on A549 cells relative to normal cells with high selectivity index values. Then, the hypoxic model that recognized to induce aggressive abilities was established in A549 cells by cobalt chloride (CoCl2) stimulation. With this model, terrein could reduce HIF-1α, a marker of hypoxia, and inhibit both migration and invasion of which the effect on invasion is more explicit. Our results demonstrated that terrein has a potential new role as the anti-aggressive phenotype by inhibiting cancer cell migration and invasion through HIF-1α reduction. © 2021, Walailak University. All rights reserved.