Publication:
Chemical constituents, and their cytotoxicity, of the rare wood decaying fungus Xylaria humosa

0
0

Issued Date

2014

Resource Type

Article

File Type

application/pdf

ISSN

1934578X

DOI

10.1177/1934578x1400900205

Other identifier(s)

2-s2.0-84894505576

Rights Holder(s)

Scopus

Bibliographic Citation

Natural Product Communications. Vol 9, No.2 (2014), p.157-158

Suggested Citation

Sodngam S., Sawadsitang S., Suwannasai N., Mongkolthanaruk W. Chemical constituents, and their cytotoxicity, of the rare wood decaying fungus Xylaria humosa. Natural Product Communications. Vol 9, No.2 (2014), p.157-158. doi:10.1177/1934578x1400900205 Retrieved from: https://hdl.handle.net/20.500.14740/7138

Title

Chemical constituents, and their cytotoxicity, of the rare wood decaying fungus Xylaria humosa

Author(s)

Sodngam S.
 Sawadsitang S.
 Suwannasai N.
 Mongkolthanaruk W.

Abstract

Samples of Xylaria humosa, a rare species of Xylariaceae, were collected during an investigation into the diversity of the fungus in the Phu Khieo Wildlife Sanctuary, Thailand. Nine compounds were isolated from the species and their structures elucidated by spectroscopic methods. The compounds were ergosterol (1), ergosterol peroxide (2), two meroterpenoids, chevalone B and C (3-4), together with five indole alkaloids, tryptoquivaline L (5), tryptoquivaline M (6), fiscalin A (7), epi-fiscalin A (8) and epi-fiscalin C (9). Compounds 2-9 exhibited variable cytotoxic activity against KB, NCI-H187 and MCF-7 cell lines.

Subject(s)

Chevalone B
 Chevalone C
 Cytotoxic agent
 Doxorubicin
 Ellipticine
 Epi fiscalin A
 Epi fiscalin C
 Ergosterol
 Ergosterol peroxide
 Fiscalin A
 Fungal extract
 Indole alkaloid
 Quinazolinone derivative
 Tamoxifen
 Terpenoid
 Tryptoquivaline
 Unclassified drug
 Article
 Breast cancer
 Cell strain MCF 7
 Chemical composition
 Controlled study
 Cytotoxicity
 Cytotoxicity assay
 Fermentation
 Human
 Human cell
 IC 50
 Lung small cell cancer
 Nonhuman
 Rare species
 Spectroscopy
 Squamous cell carcinoma
 Thailand
 Wood decay fungus
 Xylaria humosa
 Xylariales
 Antineoplastic Agents
 Cell Line, Tumor
 Humans
 Wood
 Xylariales

View online Resources

Research Projects

Organizational Units

Journal Issue

URI

https://hdl.handle.net/20.500.14740/7138

Collections

Scopus: Year 1983-2021

Endorsement

Review

Supplemented By

Referenced By