Publication:
Antimicrobial and antioxidant activities of traditional Thai herbal remedies for aphthous ulcers

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Issued Date

2010

Resource Type

Article

File Type

application/pdf

ISSN

0951418X

DOI

10.1002/ptr.3158

Other identifier(s)

2-s2.0-78649427006

Rights Holder(s)

Scopus

Bibliographic Citation

Phytotherapy Research. Vol 24, No.10 (2010), p.1514-1519

Suggested Citation

Mekseepralard C., Kamkaen N., Wilkinson J.M. Antimicrobial and antioxidant activities of traditional Thai herbal remedies for aphthous ulcers. Phytotherapy Research. Vol 24, No.10 (2010), p.1514-1519. doi:10.1002/ptr.3158 Retrieved from: https://hdl.handle.net/20.500.14740/7539

Title

Antimicrobial and antioxidant activities of traditional Thai herbal remedies for aphthous ulcers

Author(s)

Mekseepralard C.
 Kamkaen N.
 Wilkinson J.M.

Abstract

Four medicinal plants (Quercus infectoria, Kaempferia galanga, Coptis chinensis and Glycyrrhiza uralensis) as well as one traditional Thai treatment for aphthous ulcers based on these four plants were tested for antimicrobial activity. MIC values for a range of bacteria and Candida albicans were determined, with both type strains and clinical isolates being used. Antioxidant activity was determined using the ABTS radical scavenging assay. Among the four plants, Q. infectoria showed antimicrobial activity against Staphylococcus aureus with an MIC of 0.41 mg/mL, while C. chinensis showed antifungal activity against C. albicans with an MIC of 6.25 mg/mL. Activity was also shown against a range of other organisms including Salmonella typhi, Serratia marcescens, Vibrio cholerae, Vibrio parahaemolyticus, Pseudomonas aeruginosa and Enterococcus faecalis. The antimicrobial activity of the traditional aphthous ulcer preparation (a powder) was comparable to that for the individual plant extracts, however, incorporation of the powder into a gel formulation resulted in the loss of almost all activity. All extracts, with the exception of K. galanga, also showed good antioxidant activity. This study supports the traditional use of these plants and suggests that they may also be useful in the treatment of other infections. © 2010 John Wiley & Sons, Ltd.

Subject(s)

Antiinfective agent
 Antioxidant
 Coptis chinensis extract
 Glycyrrhiza uralensis extract
 Kaempferia galanga extract
 Plant extract
 Quercus infectoria extract
 Scavenger
 Unclassified drug
 Antimicrobial activity
 Antioxidant activity
 Aphthous ulcer
 Article
 Assay
 Bacterial strain
 Candida albicans
 Controlled study
 Enterococcus faecalis
 Glycyrrhiza uralensis
 Herbal medicine
 Minimum inhibitory concentration
 Nonhuman
 Pseudomonas aeruginosa
 Salmonella typhi
 Scavenging system
 Serratia marcescens
 Staphylococcus aureus
 Vibrio cholerae
 Vibrio parahaemolyticus
 Anti-Infective Agents
 Antioxidants
 Microbial Sensitivity Tests
 Plant Extracts
 Plants, Medicinal
 Powders
 Stomatitis, Aphthous
 Thailand
 Candida albicans
 Coptis chinensis
 Enterococcus faecalis
 Glycyrrhiza uralensis
 Kaempferia galanga
 Pseudomonas aeruginosa
 Quercus infectoria
 Salmonella typhi
 Serratia marcescens
 Staphylococcus aureus
 Vibrio cholerae
 Vibrio parahaemolyticus

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URI

https://hdl.handle.net/20.500.14740/7539

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Scopus: Year 1983-2021

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