Emerging role of sentinel lymph node mapping for gynecologic oncology in the new era

Abstract

This study aims to update a review of the recent literature on sentinel lymph node biopsy (SLNB) in common gynecological cancer. Fifty-eight published English-language articles were obtained. Most of the well-designed studies were conducted in the patient with vulvar, endometrial, and cervical cancer, but SLNB data in ovarian cancer is limited. The result of diagnostic accuracy reported a satisfactory with a high detection rate, a high sensitivity, and an acceptable febrile neutropenia (FN) rate in all cancer types. The technique of SLNB in vulvar prefers combined radiocolloid and dye methods. The common technique in endometrial and cervical cancer is laparoscopic or robotic-assisted surgery with cervical indocyanine green (ICG) injection injection while laparotomy is the most frequently used in studies of ovarian cancer. This evidence supports that SLN mapping could replace the traditional lymphadenectomy in early-stage vulvar, endometrial, and cervical cancer. The result of feasibility and efficacy of this procedure in ovarian cancer is promising but more studies are required. © 2019 S.O.G. CANADA Inc.. All rights reserved.