Publication:
Vasoprotective effects of rice bran water extract on rats fed with high-fat diet

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Issued Date

2016

Resource Type

Article

File Type

application/pdf

ISSN

22211691

DOI

10.1016/j.apjtb.2016.07.009

Other identifier(s)

2-s2.0-84992197944

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Asian Pacific Journal of Tropical Biomedicine. Vol 6, No.9 (2016), p.778-784

Suggested Citation

Munkong N., Hansakul P., Yoysungnoen B., Wongnoppavich A., Sireeratawong S., Kaendee N., Lerdvuthisopon N. Vasoprotective effects of rice bran water extract on rats fed with high-fat diet. Asian Pacific Journal of Tropical Biomedicine. Vol 6, No.9 (2016), p.778-784. doi:10.1016/j.apjtb.2016.07.009 Retrieved from: https://hdl.handle.net/20.500.14740/5260

Title

Vasoprotective effects of rice bran water extract on rats fed with high-fat diet

Author(s)

Munkong N.
 Hansakul P.
 Yoysungnoen B.
 Wongnoppavich A.
 Sireeratawong S.
 Kaendee N.
 Lerdvuthisopon N.

Abstract

Objective To elucidate the protective effects of rice bran water extract on the expression of endothelial nitric oxide synthase (eNOS), nuclear factor-kappa B (NF-κB), and a cluster of differentiation 36 (CD36) in the vasculature of high-fat diet-fed rats. Methods Male Sprague-Dawley rats were divided into three groups. Group I served as control, Group II was treated with high-fat diet, and Group III was treated with high-fat diet and rice bran water extract at 2 205 mg/kg/day. After four weeks, the metabolic parameters, malondialdehyde as a marker of oxidative stress, and histological features of the aorta were evaluated. The levels of transcripts and proteins in aorta were determined by real-time PCR and Western blot analysis, respectively. Results In comparison with the Group II, rice bran water extract administration resulted in a significant reduction in body weight, visceral fat tissue weights, blood glucose levels, and serum total-cholesterol and free fatty acid levels in Group III. Serum triglyceride levels tended to decrease in the Group III. Also, rice bran water extract administration obviously decreased malondialdehyde levels in both serum and aorta. Interestingly, rice bran water extract treatment demonstrated a significant up-regulation of eNOS expression and down-regulation of NF-κB p65 and CD36 expressions. Nonetheless, all groups showed normal histology of aorta. Conclusions Rice bran water extract exhibited vasoprotective effects in the high-fat diet-induced obesity condition by modulating the expression of eNOS, NF-κB, and CD36 and metabolic parameters. © 2016 Hainan Medical University

Subject(s)

CD36 antigen
 Cholesterol
 Endothelial nitric oxide synthase
 Fatty acid
 Glucose
 Herbaceous agent
 High density lipoprotein cholesterol
 Low density lipoprotein cholesterol
 Malonaldehyde
 Rice bran extract
 Transcription factor RelA
 Triacylglycerol
 Unclassified drug
 Water
 Animal experiment
 Animal model
 Animal tissue
 Aorta
 Article
 Caloric intake
 Cholesterol blood level
 Controlled study
 Down regulation
 Drug effect
 Fatty acid blood level
 Gene expression
 Glucose blood level
 Histopathology
 Intraperitoneal fat
 Lipid diet
 Male
 Metabolic syndrome X
 Nonhuman
 Organ weight
 Priority journal
 Protein expression
 Rat
 Real time polymerase chain reaction
 Rice bran
 Sprague Dawley rat
 Tissue weight
 Triacylglycerol blood level
 Upregulation
 Vasoprotective effect
 Weight gain
 Weight reduction
 Western blotting

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URI

https://hdl.handle.net/20.500.14740/5260

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Scopus: Year 1983-2021

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