Publication:
Gnathostoma spinigerum: Immunodepression in experimental infected mice

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Issued Date

2012

Resource Type

Article

File Type

application/pdf

ISSN

144894

DOI

10.1016/j.exppara.2012.08.002

Other identifier(s)

2-s2.0-84867330892

Rights Holder(s)

Scopus

Bibliographic Citation

Experimental Parasitology. Vol 132, No.3 (2012), p.320-326

Suggested Citation

Saksirisampant W., Thaisom S., Ratanavararak M., Thanomsub B.W. Gnathostoma spinigerum: Immunodepression in experimental infected mice. Experimental Parasitology. Vol 132, No.3 (2012), p.320-326. doi:10.1016/j.exppara.2012.08.002 Retrieved from: https://hdl.handle.net/20.500.14740/6925

Title

Gnathostoma spinigerum: Immunodepression in experimental infected mice

Author(s)

Saksirisampant W.
 Thaisom S.
 Ratanavararak M.
 Thanomsub B.W.

Abstract

Mice were infected with 8- or 25-infective worms of advanced third stage Gnathostoma spinigerum larvae (L3) which were obtained from natural infected eels. On day 14, 60 and 200 post infections (PI), spleen cells of infected mice were tested for lymphoproliferative responses in vitro against the mitogen and specific L3 somatic antigen in order to clarify the cellular immune status of the host upon this nematode infection. Reduced responsiveness to Con A was observed in infected mice. These depressed responses were more pronounced in chronically infected mice (day 200, PI) than in day 14 and day 60, PI. There was no significant difference of lymphoproliferative response between groups of high (25 L3) and low (8 L3)-infective dose in the chronic readily stage. Regarding to the L3 somatic Ag stimulation, the depressed response was obviously detected in high dose and chronic infection. Our results demonstrated that in this G. spinigerum-mouse system T-cell response is defective. The depression could be reversible and was associated with active infection because it was abolished by anthelmintic (ivermectin) treatment. This study shows the involvement of Th-2 response to this nematode in regulating T cell proliferation. © 2012 Elsevier Inc.

Subject(s)

Concanavalin A
 Ivermectin
 Mitogenic agent
 Silver
 Animal cell
 Animal experiment
 Animal model
 Animal tissue
 Antigen specificity
 Article
 Cellular immunity
 Controlled study
 Dose response
 Experimental infection
 Experimental mouse
 Gnathostomiasis
 Immune deficiency
 In vitro study
 Lymphocyte proliferation
 Male
 Mitogenicity
 Mouse
 Nonhuman
 Priority journal
 Single drug dose
 Somatic cell
 T lymphocyte activation
 Animals
 Antigens, Helminth
 Antiparasitic Agents
 Cell Proliferation
 Concanavalin A
 Gnathostoma
 Gnathostomiasis
 Ivermectin
 Lymphocytes
 Male
 Mice
 Mitogens
 Smegmamorpha
 Spleen
 Gnathostoma spinigerum
 Mus

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URI

https://hdl.handle.net/20.500.14740/6925

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Scopus: Year 1983-2021

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