Publication:
Chemical composition of essential oil from piper sarmentosum fruit and neuroprotective activity

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Issued Date

2021

Resource Type

Article

Language

eng

File Type

application/pdf

ISSN

26160684

DOI

10.26538/tjnpr/v5i2.18

Other identifier(s)

2-s2.0-85102560249

Rights Holder(s)

Scopus

Bibliographic Citation

Tropical Journal of Natural Product Research. Vol 5, No.2 (2021), p.319-323

Suggested Citation

Athikomkulchai S., Loyfar P., Jira-Arnon R., Tadtong S., Sareedenchai V., Phattanaphakdee W., Ruangrungsi N., Chittasupho C. Chemical composition of essential oil from piper sarmentosum fruit and neuroprotective activity. Tropical Journal of Natural Product Research. Vol 5, No.2 (2021), p.319-323. doi:10.26538/tjnpr/v5i2.18 Retrieved from: https://hdl.handle.net/20.500.14740/8089

Title

Chemical composition of essential oil from piper sarmentosum fruit and neuroprotective activity

Author(s)

Athikomkulchai S.
 Loyfar P.
 Jira-Arnon R.
 Tadtong S.
 Sareedenchai V.
 Phattanaphakdee W.
 Ruangrungsi N.
 Chittasupho C.

Abstract

A number of complementary medicines have been investigated for their neuroprotection and treatment of neurodegenerative diseases. This study aimed to analyze the chemical compounds and the neuroprotective activity Piper sarmentosum Roxb. fruit essential oil. The essential oil from the fruits of P. sarmentosum (Piperaceae) was extracted by hydrodistillation. Chemical components of the oil were analyzed by Gas chromatography-Mass spectrometry (GC-MS). The effects of essential oil from P. sarmentosum fruit on P19-derived neuron cell viability, neuron length, and branching numbers were investigated. The results showed that the yield of essential oil obtained from P. sarmentosum fruit distillation was 1.47% w/w. The essential oil from P. sarmentosum fruit contained major compounds, namely; myristicin (88.9%), E-caryophyllene (3.7%), elemicin (1.4%), pentadecane (1.0%), apiole (1.0%), α-copaene (0.7%), and β-copaene (0.2%). The essential oil at 1 and 10 ng/mL significantly increased cell viability, elongated neuron length, and enhanced branching numbers. Therefore, it was suggested that the oil extracted from P. sarmentosum fruit may have promising neuroprotective and neuritogenic effects on neurons and prevent neurodegenerative diseases. © 2021 Athikomkulchai et al.

Subject(s)

Caryophyllene
 Copaene
 Elemicin
 Essential oil
 Myristicin
 Neuroprotective agent
 Piper sarmentosum extract
 Plant extract
 Quercetin
 Thymol
 Unclassified drug
 Animal cell
 Antiinflammatory activity
 Apoptosis
 Article
 Cell viability
 Controlled study
 Degenerative disease
 Distillation
 Drug analysis
 Embryoid body
 Endoplasmic reticulum stress
 Fruit
 Gas chromatography
 High performance liquid chromatography
 Hydrodistillation
 IC50
 Low drug dose
 Mass spectrometry
 MTT assay
 Nerve cell
 Neurite outgrowth
 Neuritogenic activity
 Neuroprotection
 Nonhuman
 Nutmeg
 Oxidative stress
 Pharmacology
 Piper sarmentosum
 Rosemary
 Spinal ganglion
 XTT assay

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URI

https://hdl.handle.net/20.500.14740/8089

Collections

Scopus: Year 1983-2021

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