Optimal parameters of electroporation for gene and tissue

Abstract

The mechanism of electroporation has been successfully exploited to deliver gene and drugs into tissue. Electroporation has become an important role to enhance the delivery of genes into tissue. This technique can also be effectively utilized with marginal effect on viability. Electroporation technique can also provide high transfection efficiency. Therefore, there is an increasing interest in electroporation method for delivering gene into tissue. One important area is the delivery of genes into tissues as a therapy. This paper presents the overview of optimal parameters of electroporation for gene and tissue in vivo. This article reviews the obtained results, including the background of electroporation and essential parameters for transfection. This study discusses the evidence based on the success of delivering gene in vivo and effective delivery of drugs in electroporation. © 2011 IEEE.