Publication:
Effects of Curcuma comosa on the expression of atherosclerosis-related cytokine genes in rabbits fed a high-cholesterol diet

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Issued Date

2011

Resource Type

Article

File Type

application/pdf

ISSN

3788741

DOI

10.1016/j.jep.2011.01.006

Other identifier(s)

2-s2.0-79954425672

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Journal of Ethnopharmacology. Vol 134, No.3 (2011), p.608-613

Suggested Citation

Charoenwanthanang P., Lawanprasert S., Phivthong-Ngam L., Piyachaturawat P., Sanvarinda Y., Porntadavity S. Effects of Curcuma comosa on the expression of atherosclerosis-related cytokine genes in rabbits fed a high-cholesterol diet. Journal of Ethnopharmacology. Vol 134, No.3 (2011), p.608-613. doi:10.1016/j.jep.2011.01.006 Retrieved from: https://hdl.handle.net/20.500.14740/7341

Title

Effects of Curcuma comosa on the expression of atherosclerosis-related cytokine genes in rabbits fed a high-cholesterol diet

Author(s)

Charoenwanthanang P.
 Lawanprasert S.
 Phivthong-Ngam L.
 Piyachaturawat P.
 Sanvarinda Y.
 Porntadavity S.

Abstract

Aim of the study: Curcuma comosa has been known to have potential use in cardiovascular diseases, but its immunoregulatory role in atherosclerosis development and liver toxicity has not been well studied. We therefore investigated the effects of Curcuma comosa on the expression of atherosclerosis-related cytokine genes in rabbits fed a high-cholesterol diet. Materials and methods: Twelve male New Zealand White rabbits were treated with 1.0% cholesterol for one month and were subsequently treated with 0.5% cholesterol either alone, or in combination with 5 mg/kg/day of simvastatin or with 400 mg/kg/day of Curcuma comosa powder for three months. The expression of IL-1, MCP-1, TNF-α, IL-10, and TGF-β in the isolated abdominal aorta and liver were determined by real-time RT-PCR. Liver toxicity was determined by hepatic enzyme activity. Results: Curcuma comosa significantly decreased the expression of pro-inflammatory cytokines, leading to a stronger reduction in IL-1, MCP-1, and TNF-α expression compared to that was suppressed by simvastatin treatment. However, neither Curcuma comosa nor simvastatin affected the expression of anti-inflammation cytokines. In the liver, Curcuma comosa insignificantly decreased the expression of pro-inflammatory cytokines and significantly increased the expression of the anti-inflammatory cytokine IL-10 without altering the activity of hepatic enzymes. In contrast, simvastatin significantly increased the MCP-1 and TNF-α expressions and serum ALT level, without affecting the expression of anti-inflammatory cytokines. Conclusions: In this study, we demonstrated that Curcuma comosa exerts anti-inflammatory activity in the aorta and liver without causing liver toxicity, indicating that Curcuma comosa is a potential candidate as an alternative agent in cardiovascular disease therapy. © 2011 Elsevier Ireland Ltd.

Subject(s)

Cholesterol
 Curcuma comosa extract
 Cytokine
 Interleukin 1
 Interleukin 10
 Monocyte chemotactic protein 1
 Plant extract
 Simvastatin
 Transforming growth factor beta
 Tumor necrosis factor alpha
 Unclassified drug
 Abdominal aorta
 Animal experiment
 Animal model
 Antiinflammatory activity
 Article
 Atherosclerosis
 Cholesterol diet
 Controlled study
 Curcuma comosa
 Drug effect
 Drug safety
 Gene expression regulation
 Hypercholesterolemia
 Liver toxicity
 Male
 Medicinal plant
 Nonhuman
 Nucleotide sequence
 Protein expression
 Rabbit
 Animals
 Aorta, Abdominal
 Atherosclerosis
 Base Sequence
 Cholesterol, Dietary
 Curcuma
 Cytokines
 DNA Primers
 Hypercholesterolemia
 Liver
 Liver Function Tests
 Male
 Plants, Medicinal
 Rabbits
 Reverse Transcriptase Polymerase Chain Reaction
 Curcuma comosa
 Oryctolagus cuniculus

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URI

https://hdl.handle.net/20.500.14740/7341

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Scopus: Year 1983-2021

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