Publication:
Oxidative pathways in cardiovascular disease: Roles, mechanisms, and therapeutic implications

1
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Issued Date

2001

Resource Type

Review

File Type

application/pdf

ISSN

1637258

DOI

10.1016/S0163-7258(00)00114-5

Other identifier(s)

2-s2.0-0035055046

Rights Holder(s)

Scopus

Bibliographic Citation

Pharmacology and Therapeutics. Vol 89, No.2 (2001), p.187-206

Suggested Citation

Wattanapitayakul S.K., Bauer J.A. Oxidative pathways in cardiovascular disease: Roles, mechanisms, and therapeutic implications. Pharmacology and Therapeutics. Vol 89, No.2 (2001), p.187-206. doi:10.1016/S0163-7258(00)00114-5 Retrieved from: https://hdl.handle.net/20.500.14740/6904

Title

Oxidative pathways in cardiovascular disease: Roles, mechanisms, and therapeutic implications

Author(s)

Wattanapitayakul S.K.
 Bauer J.A.

Abstract

Despite some recent declines, cardiovascular disease (CVD) remains the major cause of death in the United States and worldwide. Most recent advances in the treatment of CVD states have been produced by inhibition of mechanisms involved in disease progress. Many studies conducted in the last decade have illustrated increased biological oxidative pathways during CVD in animals and humans. Thus, increased production of reactive oxygen species may be a unifying mechanism in CVD progression, and antioxidants may have therapeutic value in this setting. In this review we address the following questions: Do oxidative mechanisms play a role in CVD? Where do the oxidants come from? What are the relevant oxidative events? What are the therapeutic implications? © 2001 Elsevier Science Inc.

Subject(s)

Alpha tocopherol
 Antioxidant
 Arginine
 Ascorbic acid
 Beta carotene
 Colestipol
 Cytokine
 Fatty acid
 Glutathione
 Lipoprotein
 Nicotinic acid
 Nitric oxide
 Nitric oxide synthase
 Reactive oxygen metabolite
 Reduced nicotinamide adenine dinucleotide dehydrogenase
 Reduced nicotinamide adenine dinucleotide phosphate oxidase
 Retinol
 Retinol palmitate
 Superoxide dismutase
 Xanthine oxidase
 Apoptosis
 Calcium signaling
 Cardiovascular disease
 Cause of death
 Cell death
 Cell infiltration
 Coronary artery disease
 Disease course
 Electron transport
 Gene expression
 Heart failure
 Heart infarction
 Heart muscle necrosis
 Human
 Hypertension
 Lipid metabolism
 Mitochondrial respiration
 Nonhuman
 Oxidative stress
 Priority journal
 Protein metabolism
 Protein phosphorylation
 Review
 Signal transduction
 Treatment outcome
 Vitamin supplementation
 Animals
 Antioxidants
 Cardiovascular Diseases
 Cell Death
 Dietary Supplements
 Humans
 Nitric Oxide
 Oxidants
 Reactive Oxygen Species

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URI

https://hdl.handle.net/20.500.14740/6904

Collections

Scopus: Year 1983-2021

Endorsement

Review

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