Publication:
Assessment of preeclampsia risk by use of serum ionized magnesium-based equation

2
0

Issued Date

2018

Resource Type

Article

File Type

application/pdf

ISSN

0886022X

DOI

10.1080/0886022X.2017.1422518

Other identifier(s)

2-s2.0-85046876060

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Renal Failure. Vol 40, No.1 (2018), p.99-106

Suggested Citation

Kreepala C., Kitporntheranunt M., Sangwipasnapaporn W., Rungsrithananon W., Wattanavaekin K. Assessment of preeclampsia risk by use of serum ionized magnesium-based equation. Renal Failure. Vol 40, No.1 (2018), p.99-106. doi:10.1080/0886022X.2017.1422518 Retrieved from: https://hdl.handle.net/20.500.14740/5816

Title

Assessment of preeclampsia risk by use of serum ionized magnesium-based equation

Author(s)

Kreepala C.
 Kitporntheranunt M.
 Sangwipasnapaporn W.
 Rungsrithananon W.
 Wattanavaekin K.

Abstract

Background: Preeclampsia is a common medical complication in pregnancy. It has been reported to be associated with decreased serum magnesium levels. However, there has not been evidence demonstrating utilization of change in magnesium for prediction of preeclampsia. The purpose of this study was to develop magnesium fraction-based equations which took other significant clinical risk factors into consideration for prediction of preeclampsia. Methods: We collected serum total and ionized magnesium ionized magnesium levels from 84 pregnant women diagnosed with preeclampsia after week 20 of pregnancy. The ionized magnesium fraction was then calculated by the percentage ratio of ionized and total magnesium level. Results: Sixty-four (76.19%) women had normal pregnancy and 20 (23.81%) developed preeclampsia. The ionized magnesium fraction was significantly lower in preeclampsia group (23.95 ± 4.7% vs. 26.28 ± 2.3%, p¼.04). Additionally, lower ionized magnesium fraction (24.67%), teenage and elderly primigravida were significantly associated with preeclampsia (OR¼4.41, 95% CI: 1.46-13.40, OR¼5.47, 95% CI: 1.85-35.42 and OR¼11.11, 95% CI: 1.09-113.78, respectively). Consequently, we attempted to develop ionized magnesium fraction-based equations calculate risk scores for preeclampsia. The area of ROC for predictive accuracy of the model was 0.77 (p<.001) and ROC suggested that the score of 0.27 would be a threshold for screening preeclampsia with 70% sensitivity and 81% specificity. Conclusions: Ionized magnesium fraction may have been appropriate for screening of preeclampsia. We suggested blood testing on total and ionized magnesium concentrations as well as calculation of ionized magnesium fraction in addition to routine antenatal care for better screening of the disease. © 2018 The Author(s).

Subject(s)

Magnesium
 Divalent cation
 Magnesium
 Adolescent pregnancy
 Adult
 Article
 Blood sampling
 Calculation
 Clinical assessment
 Cohort analysis
 Controlled study
 Descriptive research
 Diagnostic accuracy
 Diastolic blood pressure
 Female
 Gestational age
 Human
 Magnesium blood level
 Major clinical study
 Maternal age
 Prediction
 Preeclampsia
 Pregnant woman
 Prenatal care
 Primigravida
 Priority journal
 Receiver operating characteristic
 Risk assessment
 Risk factor
 Sensitivity and specificity
 Serum ionized magnesium based equation
 Systolic blood pressure
 Age
 Blood
 Feasibility study
 Predictive value
 Preeclampsia
 Pregnancy
 Procedures
 Young adult
 Adult
 Age Factors
 Cations, Divalent
 Cohort Studies
 Feasibility Studies
 Female
 Humans
 Magnesium
 Pre-Eclampsia
 Predictive Value of Tests
 Pregnancy
 Risk Assessment
 Risk Factors
 ROC Curve
 Young Adult

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URI

https://hdl.handle.net/20.500.14740/5816

Collections

Scopus: Year 1983-2021

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