Publication: In Vitro Antioxidant Activity Study of Novel Chromone Derivatives
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Issued Date
2012
Resource Type
File Type
application/pdf
ISSN
17470277
Other identifier(s)
2-s2.0-84860477134
Rights Holder(s)
Scopus
Bibliographic Citation
Chemical Biology and Drug Design. Vol 79, No.6 (2012), p.981-989
Suggested Citation
Phosrithong N., Samee W., Nunthanavanit P., Ungwitayatorn J. In Vitro Antioxidant Activity Study of Novel Chromone Derivatives. Chemical Biology and Drug Design. Vol 79, No.6 (2012), p.981-989. doi:10.1111/j.1747-0285.2012.01368.x Retrieved from: https://hdl.handle.net/20.500.14740/7042
Abstract
Forty-eight chromone derivatives were evaluated for their antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl free radical scavenging assay, ferrous ions (Fe 2+) chelating activity test, total antioxidant activity test (Ferric thiocyanate and Thiobarbituric acid methods), and total reductive capability (potassium ferricyanide reduction). 7,8-Dihydroxy-2-(3′-trifluoromethylphenyl)-3-(3″-trifluoromethylbenzoyl) chromone 32 showed stronger radical scavenging and metal chelating activities than butylated hydroxytoluene, vitamin E, and trolox. Chromone derivatives that exhibited good radical scavenging and metal chelating also displayed strong total antioxidant and reductive power activities. The results obtained from this study indicated that the synthesized chromone derivatives have remarkable antioxidant activity. © 2012 John Wiley & Sons A/S.