Publication: Relationship between mast cells and hepatic myofibroblasts induced cirrhosis rats
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Issued Date
2017
Resource Type
File Type
application/pdf
ISSN
1252208
Other identifier(s)
2-s2.0-85074976745
Rights Holder(s)
Scopus
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol 100, No.10 (2017), p.S95-S100
Suggested Citation
Poonkhum R., Rodniem S., Kaewnoonual N., Nilbu-Nga C., Pradidarcheep W. Relationship between mast cells and hepatic myofibroblasts induced cirrhosis rats. Journal of the Medical Association of Thailand. Vol 100, No.10 (2017), p.S95-S100. Retrieved from: https://hdl.handle.net/20.500.14740/4351
Abstract
Objective: The hepatic myofibroblasts (hepatic MFs) can be divided into 3 groups: (a) portal/septal MFs; (b) activated hepatic stellate cell myofibroblasts (HSC/MFs); and (c) interface myofibroblasts (IF/MFs). The portal/septal MFs situated in portal triad, HSC/MFs located in space of Disse and IF/MFs lay in the rim of hepatic nodule. This study was aimed to elucidate the relationship between mast cells and hepatic MFs in cirrhotic rats induced by thioacetamide (TAA). Material and Method: The rats were divided into two groups: control group, TAA-induced. The rats were treated with TAA administration (200 mg/kg) 3 times per week to induce cirrhosis (TAA-induced cirrhosis group). The hepatic MFs and mast cells were demonstrated by light and transmission electron microscopy. Results: The hepatic MFs were often seen to locate in the connective tissue of cirrhotic liver. HSC/MF localized in space of Disse adjacent to mast cells. IF/MFs were also present at the margin of hepatic nodules closed to mast cell. Mast cells were predominantly found together with plasma cells in portal areas in proximity to lymphatic capillary. Conclusion: The present study demonstrated that mast cells were usually situated in close vicinity to the hepatic MFs and lymphatic capillary. It is probable that mast cells directly or indirectly involved in fibrogenesis and lymphangiogenesis in cirrhotic liver. © 2017 Medical Association of Thailand. All rights reserved.
Subject(s)
Horseradish peroxidase
Thioacetamide
Animal experiment
Animal tissue
Article
Connective tissue
Controlled study
Decapitation
Experimental liver cirrhosis
Fibrogenesis
Hepatic portal vein
Immunohistochemistry
Liver cell
Lymphangiogenesis
Male
Mast cell
Microscopy
Myofibroblast
Nonhuman
Plasma cell
Rat
Toxic hepatitis
Transmission electron microscopy
Thioacetamide
Animal experiment
Animal tissue
Article
Connective tissue
Controlled study
Decapitation
Experimental liver cirrhosis
Fibrogenesis
Hepatic portal vein
Immunohistochemistry
Liver cell
Lymphangiogenesis
Male
Mast cell
Microscopy
Myofibroblast
Nonhuman
Plasma cell
Rat
Toxic hepatitis
Transmission electron microscopy