Publication:
The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves

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Issued Date

2008

Resource Type

Article

File Type

application/pdf

ISSN

3788741

DOI

10.1016/j.jep.2007.12.010

Other identifier(s)

2-s2.0-40249085612

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of Ethnopharmacology. Vol 116, No.3 (2008), p.439-446

Suggested Citation

Chumark P., Khunawat P., Sanvarinda Y., Phornchirasilp S., Morales N.P., Phivthong-Ngam L., Ratanachamnong P., Srisawat S., Pongrapeeporn K.-U.S. The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves. Journal of Ethnopharmacology. Vol 116, No.3 (2008), p.439-446. doi:10.1016/j.jep.2007.12.010 Retrieved from: https://hdl.handle.net/20.500.14740/4087

Title

The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves

Author(s)

Chumark P.
 Khunawat P.
 Sanvarinda Y.
 Phornchirasilp S.
 Morales N.P.
 Phivthong-Ngam L.
 Ratanachamnong P.
 Srisawat S.
 Pongrapeeporn K.-U.S.

Abstract

Moringa oleifera is used in Thai traditional medicine as cardiotonic. Recent studies demonstrated its hypocholesterolaemic effect. However, to be clinically useful, more scientific data are needed. Aim of the Study: We investigated the antioxidant, hypolipidaemic and antiatherosclerotic activities of Moringa oleifera leaf extract. Materials and Methods: Scavenging activity of the extract on 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH), and the inhibitory effect on Cu2+-induced low-density lipoprotein (LDL) oxidation were determined in in vitro experiment. The effects of the extract on cholesterol levels, conjugated diene (CD) and thiobarbituric acid reactive substances (TBARS) and plaque formations in cholesterol-fed rabbits were investigated. Results: We found that in scavenging DPPH radicals the extract and Trolox® had IC50 of 78.15 ± 0.92 and 2.14 ± 0.12 μg/ml, respectively. The extract significantly (P < 0.05) prolonged the lag-time of CD formation and inhibited TBARS formation in both in vitro and ex vivo experiments in a dose-dependent manner. In hypercholesterol-fed rabbits, at 12 weeks of treatment, it significantly (P < 0.05) lowered the cholesterol levels and reduced the atherosclerotic plaque formation to about 50 and 86%, respectively. These effects were at degrees comparable to those of simvastatin. Conclusions: The results indicate that this plant possesses antioxidant, hypolipidaemic and antiatherosclerotic activities and has therapeutic potential for the prevention of cardiovascular diseases. © 2007 Elsevier Ireland Ltd. All rights reserved.

Subject(s)

1,1 diphenyl 2 picrylhydrazyl
 Alkadiene
 Cholesterol
 Copper
 Low density lipoprotein
 Moringa oleifera extract
 Simvastatin
 Thiobarbituric acid reactive substance
 Trolox C
 Analytic method
 Animal experiment
 Animal model
 Animal tissue
 Anticoagulation
 Antioxidant activity
 Article
 Atherosclerotic plaque
 Cholesterol blood level
 Cholesterol diet
 Comparative study
 Controlled study
 Dose response
 Hypolipemia
 Male
 Moringa oleifera
 Nonhuman
 Oxidation
 Rabbit
 Animals
 Antilipemic Agents
 Antioxidants
 Atherosclerosis
 Body Weight
 Cholesterol
 Cholesterol, Dietary
 Humans
 Lipids
 Lipoproteins, LDL
 Male
 Moringa oleifera
 Picrates
 Plant Extracts
 Plant Leaves
 Rabbits
 Simvastatin
 Thiobarbituric Acid Reactive Substances
 Vitamin E
 Water
 Moringa oleifera
 Moringaceae
 Oryctolagus cuniculus

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URI

https://hdl.handle.net/20.500.14740/4087

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Scopus: Year 1983-2021

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