Publication:
Xanthones in mangosteen juice are absorbed and partially conjugated by healthy adults

0
0

Issued Date

2012

Resource Type

Article

File Type

application/pdf

ISSN

223166

DOI

10.3945/jn.111.156992

Other identifier(s)

2-s2.0-84861142005

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of Nutrition. Vol 142, No.4 (2012), p.675-680

Suggested Citation

Chitchumroonchokchai C., Riedl K.M., Suksumrarn S., Clinton S.K., Kinghorn A.D., Failla M.L. Xanthones in mangosteen juice are absorbed and partially conjugated by healthy adults. Journal of Nutrition. Vol 142, No.4 (2012), p.675-680. doi:10.3945/jn.111.156992 Retrieved from: https://hdl.handle.net/20.500.14740/7091

Title

Xanthones in mangosteen juice are absorbed and partially conjugated by healthy adults

Author(s)

Chitchumroonchokchai C.
 Riedl K.M.
 Suksumrarn S.
 Clinton S.K.
 Kinghorn A.D.
 Failla M.L.

Abstract

The proposed health-promoting effects of the pericarp from mangosteen fruit have been attributed to a family of polyphenols referred to as xanthones. The purpose of this study was to determine the bioavailability of xanthones from 100% mangosteen juice in healthy adult participants (n = 10). Pericarp particles accounted for 1% of the mass and 99% of the xanthone concentration in the juice. The juice provided 5.3 ± 0.1 mmol/L total xanthones with α-mangostin, garcinones (C, D, and E), γ-mangostin, gartanins, and other identified xanthones accounting for 58, 2, 6, 4, and 5%, respectively. Participants ingested 60 mL mangosteen juice with a high-fat breakfast. Free and conjugated (glucuronidated/sulfated) xanthones were detected in serum and urine. There was marked variation in the AUC (762- 4030 nmol/L × h), maximum concentration (113 ± 107 nmol/L), and time to maximum concentration (3.7 ± 2.4 h) for a-mangostin in sera during the 24-h collection. Similarly, xanthones in 24-h urine ranged from 0.9 to 11.1 mmol and accounted for 2.0 ± 0.3% (range 0.3-3.4%) of the ingested dose. There were no significant differences between female and male participants in mean pharmacokinetic values of α-mangostin in serum and urinary xanthones. Only 15.4 ± 0.7% of total xanthones in pericarp particles in the juice partitioned into mixed micelles during in vitro digestion. These results show that xanthones in mangosteen juice are absorbed when ingested along with a high-fat meal, although release of xanthones from pericarp particles during digestion may be limited. © 2012 American Society for Nutrition.

Subject(s)

Alpha mangostin
 Unclassified drug
 Xanthone derivative
 Glucuronide
 Mangostin
 Sulfate
 Xanthone derivative
 Area under the curve
 Article
 Digestion
 Drug bioavailability
 Female
 Fruit juice
 Garcinia mangostana
 Human
 Human experiment
 Lipid diet
 Male
 Maximum plasma concentration
 Meal
 Micelle
 Nonhuman
 Normal human
 Pericarp
 Serum
 Time to maximum plasma concentration
 Urinalysis
 Adult
 Beverage
 Blood
 Chemistry
 Clinical trial
 Comparative study
 Electrospray mass spectrometry
 Fruit
 High performance liquid chromatography
 Intestine absorption
 Kinetics
 Limit of detection
 Metabolism
 United States
 Urine
 Garcinia mangostana
 Adult
 Beverages
 Chromatography, High Pressure Liquid
 Digestion
 Female
 Fruit
 Garcinia mangostana
 Glucuronides
 Humans
 Intestinal Absorption
 Kinetics
 Limit of Detection
 Male
 Micelles
 Ohio
 Spectrometry, Mass, Electrospray Ionization
 Sulfates
 Xanthones

View online Resources

Research Projects

Organizational Units

Journal Issue

URI

https://hdl.handle.net/20.500.14740/7091

Collections

Scopus: Year 1983-2021

Endorsement

Review

Supplemented By

Referenced By