Publication: Development of pulsatile release tablets with swelling and rupturable layers
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Issued Date
2004
Resource Type
File Type
application/pdf
ISSN
1683659
Other identifier(s)
2-s2.0-1242331818
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
Journal of Controlled Release. Vol 95, No.2 (2004), p.147-159
Suggested Citation
Sungthongjeen S., Puttipipatkhachorn S., Paeratakul O., Dashevsky A., Bodmeier R. Development of pulsatile release tablets with swelling and rupturable layers. Journal of Controlled Release. Vol 95, No.2 (2004), p.147-159. doi:10.1016/j.jconrel.2003.10.023 Retrieved from: https://hdl.handle.net/20.500.14740/6456
Abstract
A tablet system consisting of cores coated with two layers of swelling and rupturable coatings was prepared and evaluated as pulsatile drug delivery system. Cores containing buflomedil HCl as model drug were prepared by direct compression of different ratios of spray-dried lactose and microcrystalline cellulose and were then coated sequentially with an inner swelling layer containing a superdisintegrant (croscarmellose sodium) and an outer rupturable layer of ethylcellulose. The effect of core composition, level of swelling layer and rupturable coating, and magnesium stearate in rupturable layer was investigated. Mechanical properties of ethylcellulose films in the dry and wet state were characterized with a puncture test. Rupture and dissolution tests were performed using the USP XXIV paddle method at 50 rpm in 0.1 N HCl. The lag time of the pulsatile release tablets decreased with increasing amount of microcrystalline cellulose in the cores and increased with increasing levels of both swelling layer and rupturable ethylcellulose coating. Increasing levels of the ethylcellulose coating retarded the water uptake and thus prolonged the lag time. Addition of magnesium stearate to the ethylcellulose coating lowered the mechanical strength of the film and improved the robustness of the system. © 2004 Elsevier B.V. All rights reserved.
Subject(s)
Cellulose
Coatings
Drug products
Hydrochloric acid
Strength of materials
Drug release
Controlled drug delivery
Buflomedil
Croscarmellose sodium
Ethyl cellulose
Lactose
Magnesium stearate
Microcrystalline cellulose
Water
Article
Drug coating
Drug delivery system
Drug manufacture
Drug screening
Drug solubility
Priority journal
Pulsatile drug release
Spray drying
Tablet compression
Tablet formulation
Water transport
Coatings
Drug products
Hydrochloric acid
Strength of materials
Drug release
Controlled drug delivery
Buflomedil
Croscarmellose sodium
Ethyl cellulose
Lactose
Magnesium stearate
Microcrystalline cellulose
Water
Article
Drug coating
Drug delivery system
Drug manufacture
Drug screening
Drug solubility
Priority journal
Pulsatile drug release
Spray drying
Tablet compression
Tablet formulation
Water transport