Publication:
Potential of xanthones from tropical fruit mangosteen as anti-cancer agents: Caspase-dependent apoptosis induction in vitro and in mice

2
0

Issued Date

2010

Resource Type

Article

File Type

application/pdf

ISSN

2732289

DOI

10.1007/s12010-009-8903-6

Other identifier(s)

2-s2.0-77955920713

Rights Holder(s)

Scopus

Bibliographic Citation

Applied Biochemistry and Biotechnology. Vol 162, No.4 (2010), p.1080-1094

Suggested Citation

Watanapokasin R., Jarinthanan F., Jerusalmi A., Suksamrarn S., Nakamura Y., Sukseree S., Uthaisang-Tanethpongtamb W., Ratananukul P., Sano T. Potential of xanthones from tropical fruit mangosteen as anti-cancer agents: Caspase-dependent apoptosis induction in vitro and in mice. Applied Biochemistry and Biotechnology. Vol 162, No.4 (2010), p.1080-1094. doi:10.1007/s12010-009-8903-6 Retrieved from: https://hdl.handle.net/20.500.14740/7538

Title

Potential of xanthones from tropical fruit mangosteen as anti-cancer agents: Caspase-dependent apoptosis induction in vitro and in mice

Author(s)

Watanapokasin R.
 Jarinthanan F.
 Jerusalmi A.
 Suksamrarn S.
 Nakamura Y.
 Sukseree S.
 Uthaisang-Tanethpongtamb W.
 Ratananukul P.
 Sano T.

Abstract

The pericarp of mangosteen (Garcinia mangostana L.) is rich in various xanthones that are known to possess unique biological activities. In this work, we characterized the anti-proliferative and cytotoxic activities of mangosteen xanthones both in vitro and in mice. In vitro analysis with a human colorectal adenocarcinoma cell line, COLO 205, showed that mangosteen xanthones not only inhibit the proliferation of target cells but also induce their death by apoptosis that involves the activation of the caspase cascade. In vivo analysis using a mouse subcutaneous tumor model with COLO 205 cells showed that, at relatively low doses, the growth of tumors was repressed upon intratumoral administration of mangosteen xanthones. When a higher dose of mangosteen xanthones was administered, the size of tumors was reduced gradually, and, in some mice, the disappearance of tumors was seen. Histopathological evaluation and biochemical analysis of tumors that received mangosteen xanthones indicate the induction of apoptosis in tumors, which resulted in the repression of their growth and the reduction of their sizes. These results demonstrate the potential of mangosteen xanthones to serve as anti-cancer agents for the chemotherapy of cancer. © 2010 Springer Science+Business Media, LLC.

Subject(s)

Apoptosis
 Cancer Chemotherapy
 Caspases
 Garcinia mangostana L (mangosteen)
 Mangostin
 Activation analysis
 Cell culture
 Cell death
 Chemotherapy
 Tumors
 Antineoplastic agent
 Caspase
 Caspase 3
 Caspase 8
 Cytochrome c
 Mangosteen xanthone
 Unclassified drug
 Xanthone derivative
 Adenocarcinoma
 Animal experiment
 Animal model
 Animal tissue
 Antineoplastic activity
 Apoptosis
 Article
 Cell proliferation
 Cell structure
 Cell viability
 Colon adenocarcinoma
 Colorectal cancer
 Controlled study
 DNA fragmentation
 Drug cytotoxicity
 Enzyme activation
 Enzyme activity
 Enzyme release
 Fruit
 Growth inhibition
 High performance liquid chromatography
 Histopathology
 Human
 Human cell
 In vitro study
 In vivo study
 Male
 Mangosteen
 Mouse
 Nonhuman
 Signal transduction
 Tumor cell
 Tumor growth
 Tumor volume
 Animals
 Antineoplastic Agents, Phytogenic
 Apoptosis
 Caspases
 Cell Line, Tumor
 Cell Proliferation
 Colorectal Neoplasms
 Enzyme Activation
 Female
 Fruit
 Garcinia mangostana
 Humans
 Mice
 Mice, Nude
 Neoplasms
 Plant Extracts
 Xanthones
 Garcinia mangostana
 Mus

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URI

https://hdl.handle.net/20.500.14740/7538

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Scopus: Year 1983-2021

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