Publication:
The anthelmintic effects of the ethanol extract of Terminalia catappa L. leaves against the ruminant gut parasite, Fischoederius cobboldi

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Issued Date

2016

Resource Type

Article

File Type

application/pdf

ISSN

311820

DOI

10.1017/S0031182015001833

Other identifier(s)

2-s2.0-84961616828

Rights Holder(s)

Scopus

Bibliographic Citation

Parasitology. Vol 143, No.4 (2016), p.421-433

Suggested Citation

Anuracpreeda P., Chankaew K., Puttarak P., Koedrith P., Chawengkirttikul R., Panyarachun B., Ngamniyom A., Chanchai S., Sobhon P. The anthelmintic effects of the ethanol extract of Terminalia catappa L. leaves against the ruminant gut parasite, Fischoederius cobboldi. Parasitology. Vol 143, No.4 (2016), p.421-433. doi:10.1017/S0031182015001833 Retrieved from: https://hdl.handle.net/20.500.14740/5495

Title

The anthelmintic effects of the ethanol extract of Terminalia catappa L. leaves against the ruminant gut parasite, Fischoederius cobboldi

Author(s)

Anuracpreeda P.
 Chankaew K.
 Puttarak P.
 Koedrith P.
 Chawengkirttikul R.
 Panyarachun B.
 Ngamniyom A.
 Chanchai S.
 Sobhon P.

Abstract

Presently, no effective anthelmintic drugs have been used to treat and control paramphistomosis, a severe disease of ruminants. In this study, we have investigated the in vitro anthelmintic effect of the leaves of Terminalia catappa L. crude extract (TcCE) and albendazole (ABZ) on adult Fischoederius cobboldi after incubating the flukes in RPMI-1640 medium containing the TcCE at various doses and times. The TcCE-treated flukes at all dosages exhibited rapid decrease of motility, and the relative motility (RM) values were decreased sharply from start to 3 h. Worms were killed after 6 and 12 h of treatment with 1000, 1500 and 2000 g mL-1 as well as 500 g mL-1 of TcCE, respectively. By light microscopy examination, the flukes exhibited the earliest alteration in a limited area of the tegument. At scanning electron microscopy level, the flukes' tegument showed similar sequence of morphological alterations after treatment with ABZ and TcCE that consisted of swelling of ridges and folds, followed by blebbing and rupturing of the blebs, leading to the erosion, lesion and disruption of the tegument. Hence, in vivo studies should be performed to examine whether the TcCE may serve as a powerful anthelmintic drug for treatment of paramphistomosis. © Cambridge University Press 2016.

Subject(s)

Albendazole
 Anthelmintic agent
 Plant extract
 Terminalia catappa extract
 Unclassified drug
 Albendazole
 Anthelmintic agent
 Plant extract
 Anthelmintic activity
 Article
 Basement membrane
 Controlled study
 Drug effect
 Fischoederius cobboldi
 In vitro study
 Integument
 Microscopy
 Nonhuman
 Paramphistomosis
 Parasite
 Parasitosis
 Plant leaf
 Platyhelminth
 Priority journal
 Scanning electron microscopy
 Terminalia
 Terminalia catappa
 Trematode
 Animal
 Bovine
 Buffalo
 Chemistry
 Drug effects
 Movement (physiology)
 Parasitology
 Physiology
 Rumen
 Terminalia
 Trematode Infections
 Ultrastructure
 Veterinary
 Albendazole
 Animals
 Anthelmintics
 Buffaloes
 Cattle
 Microscopy, Electron, Scanning
 Movement
 Plant Extracts
 Plant Leaves
 Rumen
 Terminalia
 Trematoda
 Trematode Infections

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URI

https://hdl.handle.net/20.500.14740/5495

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Scopus: Year 1983-2021

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