Publication: Tooth movement and root resorption; The effect of ovariectomy on orthodontic force application in rats
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Issued Date
2011
Resource Type
File Type
application/pdf
ISSN
33219
Other identifier(s)
2-s2.0-79960151514
Rights Holder(s)
Scopus
Bibliographic Citation
Angle Orthodontist. Vol 81, No.4 (2011), p.570-577
Suggested Citation
Sirisoontorn I., Hotokezaka H., Hashimoto M., Gonzales C., Luppanapornlarp S., Darendeliler M.A., Yoshida N. Tooth movement and root resorption; The effect of ovariectomy on orthodontic force application in rats. Angle Orthodontist. Vol 81, No.4 (2011), p.570-577. doi:10.2319/101710-607.1 Retrieved from: https://hdl.handle.net/20.500.14740/7295
Abstract
Objective: To quantify the amount of tooth movement and orthodontically induced root resorption (OIRR) in ovariectomized rats. Materials and Methods: Five 10-week-old female Wistar rats undergoing ovariectomy (OVX) were investigated as the experimental group, and the other five without ovariectomy served as the control group. Four weeks after ovariectomy, 25-g nickel-titanium closed-coil springs were applied mesially to the maxillary left first molars. Micro-computed tomography was taken at day 0, 1, 3, 7, 14, 21, and 28. At day 28, the molars were extracted. The surface area of root resorption craters, depth, and volume were measured using electron and laser scanning microscopes. Results: Tooth movement gradually increased with time throughout 28 days. There was a significant difference in the amount of tooth movement between the control group and the OVX group. For OIRR, the OVX group showed wide and shallow root resorption craters scattered on the mesial root. The deep resorption craters were observed on the distal roots distributed in the cervical, middle, and apical thirds of the roots. Statistically significant differences were found between the control and the OVX groups in the depth and the volume of root resorption craters in the distal roots and the total volume of root resorption craters in all three roots. Conclusion: Ovariectomy affected not only tooth movement but also OIRR. Tooth movement in the OVX group was more rapid than the control group. Furthermore, the amount of OIRR in the OVX group was more severe than the control group. © 2011 by The EH Angle Education and Research Foundation, Inc.
Subject(s)
Estrogen
Animal
Article
Bone remodeling
Dental care
Female
Image processing
Methodology
Micro-computed tomography
Molar tooth
Ovariectomy
Ovary
Periodontal disease
Physiology
Radiography
Rat
Tooth disease
Wistar rat
Animals
Bone Remodeling
Dental Stress Analysis
Estrogens
Female
Image Processing, Computer-Assisted
Molar
Ovariectomy
Ovary
Rats
Rats, Wistar
Root Resorption
Tooth Movement
X-Ray Microtomography
Animal
Article
Bone remodeling
Dental care
Female
Image processing
Methodology
Micro-computed tomography
Molar tooth
Ovariectomy
Ovary
Periodontal disease
Physiology
Radiography
Rat
Tooth disease
Wistar rat
Animals
Bone Remodeling
Dental Stress Analysis
Estrogens
Female
Image Processing, Computer-Assisted
Molar
Ovariectomy
Ovary
Rats
Rats, Wistar
Root Resorption
Tooth Movement
X-Ray Microtomography