Publication:
Apolipoprotein E receptor 2 gene polymorphisms associated with dyslipidemia among thai population

2
0

Issued Date

2015

Resource Type

Article

File Type

application/pdf

ISSN

1252208

Other identifier(s)

2-s2.0-84957696150

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Journal of the Medical Association of Thailand. Vol 98, (2015), p.S85-S90

Suggested Citation

Thongket P., Rattanathanawan K., Seesom W., Sukhumsirichart W. Apolipoprotein E receptor 2 gene polymorphisms associated with dyslipidemia among thai population. Journal of the Medical Association of Thailand. Vol 98, (2015), p.S85-S90. Retrieved from: https://hdl.handle.net/20.500.14740/6060

Title

Apolipoprotein E receptor 2 gene polymorphisms associated with dyslipidemia among thai population

Author(s)

Thongket P.
 Rattanathanawan K.
 Seesom W.
 Sukhumsirichart W.

Abstract

Background: Dyslipidemia is an abnormal amount of lipids and/or lipoproteins in the blood. It is a major risk factor of coronary heart disease and atherosclerosis. Objective: This study investigated two single nucleotide polymorphisms (SNPs) in the apolipoprotein E receptor 2 (ApoER2) gene in association with risk of dyslipidemia in the Thai patients. Material and Method: Four hundred blood samples including dyslipidemia patient (200) and unrelated normal control (200) were included in this study. Serum lipids were examined. DNAs were extracted and genotyped by using polymerase chain reaction (PCR) followed by high-resolution melting (HRM) analysis. The differences in genotype distribution between patient and normal control were assessed by Chi-square test of the SPSS software version 11.5. Results: The data analysis revealed that two SNPs (rs3737984 and rs2297660) in ApoER2 gene had significant association with dyslipidemia. The rs3737984 showed significant association at p-value = 0.001, in which A alleles informed the decreased risk of dyslipidemia [odds ratio and 95% CI of A allele, 0.42 (0.28-0.65)]. In contrast, the rs2297660 exhibited strongest association with an increase risk of dyslipidemia [p-value = 0.001, odds ratio and 95% CI for the A allele was 2.38 (1.49-3.80)]. Conclusion: The rs2297660 may be used as biomarker for the risk of dyslipidemia in Thai ethnic. © 2015, Medical Association of Thailand. All rights reserved.

Subject(s)

Apolipoprotein E2
 High density lipoprotein cholesterol
 Low density lipoprotein cholesterol
 Triacylglycerol
 Lipid
 Low density lipoprotein receptor related protein
 Low density lipoprotein receptor-related protein 8
 Adult
 Apolipoprotein e receptor 2 gene
 Article
 Cholesterol blood level
 Controlled study
 DNA extraction
 DNA polymorphism
 Dyslipidemia
 Female
 Gene
 High resolution melting analysis
 Human
 Lipid blood level
 Major clinical study
 Male
 Real time polymerase chain reaction
 Single nucleotide polymorphism
 Thai (people)
 Allele
 Asian continental ancestry group
 Blood
 Case control study
 Chi square distribution
 Dyslipidemia
 Genetics
 Genotype
 Middle aged
 Polymerase chain reaction
 Risk factor
 Alleles
 Asian Continental Ancestry Group
 Case-Control Studies
 Chi-Square Distribution
 Dyslipidemias
 Female
 Genotype
 Humans
 LDL-Receptor Related Proteins
 Lipids
 Male
 Middle Aged
 Polymerase Chain Reaction
 Polymorphism, Single Nucleotide
 Risk Factors

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URI

https://hdl.handle.net/20.500.14740/6060

Collections

Scopus: Year 1983-2021

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