Publication:
Anti-inflammatory and anti-proliferative activities of chemical constituents from fungus Biscogniauxia whalleyi SWUF13-085

0
0

Issued Date

2021

Resource Type

Article

Language

eng

File Type

application/pdf

ISSN

319422

DOI

10.1016/j.phytochem.2021.112908

Other identifier(s)

2-s2.0-85112231354

Rights Holder(s)

Scopus

Bibliographic Citation

Phytochemistry. Vol 191, No. (2021)

Suggested Citation

Jantaharn P., Mongkolthanaruk W., Suwannasai N., Senawong T., Tontapha S., Amornkitbumrung V., Boonmak J., Youngme S., Mccloskey S. Anti-inflammatory and anti-proliferative activities of chemical constituents from fungus Biscogniauxia whalleyi SWUF13-085. Phytochemistry. Vol 191, No. (2021). doi:10.1016/j.phytochem.2021.112908 Retrieved from: https://hdl.handle.net/20.500.14740/8150

Title

Anti-inflammatory and anti-proliferative activities of chemical constituents from fungus Biscogniauxia whalleyi SWUF13-085

Author(s)

Jantaharn P.
 Mongkolthanaruk W.
 Suwannasai N.
 Senawong T.
 Tontapha S.
 Amornkitbumrung V.
 Boonmak J.
 Youngme S.
 Mccloskey S.

Abstract

The fungus Biscogniauxia whalleyi SWUF13-085 from the Graphostomataceae family was studied for potential anti-inflammatory and anticancer agents. A diverse array of natural products was identified. Six of which were undescribed compounds, including xylariterpenoids L-N, (1R,2S,6R,7S)-1,2-dihydroxy-α-bisabolol, 6-[(1R)-1-hydroxy-1-methyl-2-propenyl]-4-methoxy-3-methyl-2H-pyran-2-one and (1R*,4S*,5S*,7S*,10R*)-guaia-11 (12)-en-7,10-diol. Several of the isolated compounds such as bergamotene, guaiane and phthalide derivatives showed activity in both the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells with IC50 values in the range of 2.48–10.82 μg/mL and anti-proliferation against HeLa cells with IC50 values in the range of 8.64–31.16 μg/mL. While compounds such as cerebrosides A and C only exhibited inhibitory effects on NO production with IC50 values in the range of 4.45–10.28 μg/mL. © 2021 Elsevier Ltd

View online Resources

Research Projects

Organizational Units

Journal Issue

URI

https://hdl.handle.net/20.500.14740/8150

Collections

Scopus: Year 1983-2021

Endorsement

Review

Supplemented By

Referenced By