Publication: Coexisting cancers with atypical glandular abnormalities by liquid-based cytology: A retrospective study in tertiary hospital in a high cervical cancer incident country
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Issued Date
2020
Resource Type
File Type
application/pdf
ISSN
10284559
Other identifier(s)
2-s2.0-85088866188
Rights Holder(s)
Scopus
Bibliographic Citation
Taiwanese Journal of Obstetrics and Gynecology. Vol 59, No.5 (2020), p.665-668
Suggested Citation
Kengsakul M., Manchana T. Coexisting cancers with atypical glandular abnormalities by liquid-based cytology: A retrospective study in tertiary hospital in a high cervical cancer incident country. Taiwanese Journal of Obstetrics and Gynecology. Vol 59, No.5 (2020), p.665-668. doi:10.1016/j.tjog.2020.07.007 Retrieved from: https://hdl.handle.net/20.500.14740/4422
Author(s)
Abstract
Objective: To determine the incidence of coexisting cancers in women with glandular cell abnormalities detected from liquid-based cytology and to compare the detection rate of premalignant and malignant lesions among various subtypes of glandular cell abnormalities. Materials and methods: From January 2014 to December 2016, liquid-based cytology was performed in 85,517 women. Using the Bethesda system 2001 criteria, abnormal cervical cytology was diagnosed in 3650 women (4.3%). Glandular cell abnormalities were diagnosed in 110 women (0.13%). Ten women with pre-existing genital tract cancers and 13 women who lost to follow up were excluded. Clinical characteristic, colposcopic finding, and histopathological data were reviewed in 87 women. Results: High-grade premalignant and malignant lesions were diagnosed in 34 patients (39.1%). Co-existing cancer was diagnosed in 31 patients (35.6%); 15 cervical cancers (17.2%) and 16 endometrial cancers (18.4%). The detection rate of significant lesions (CIN2+ or malignant lesions) in patients with AGC-NOS was 14.9%, AGC-FN was 38.9% and AIS/adenocarcinoma was 90.9% (p < 0.001). Conclusion: Glandular cell abnormalities associated with high incidence of coexisting endometrial and cervical cancers. Comprehensive genital tract screening to evaluate gynecologic malignancy is strongly recommended in all women with glandular cell abnormalities. © 2020
Subject(s)
Adenocarcinoma
Adenocarcinoma in situ
Adult
Article
Asymptomatic disease
Cancer cytodiagnosis
Cancer screening
Clinical feature
Colposcopy
Controlled study
Endometrium cancer
Female
Follow up
Glandular cell abnormality
Histopathology
Human
Human cell
Human tissue
Liquid based cytology
Major clinical study
Medical record review
Middle aged
Retrospective study
Squamous cell carcinoma
Tertiary care center
Uterine cervix cancer
Uterine cervix cytology
Uterus bleeding
Adenocarcinoma in situ
Adult
Article
Asymptomatic disease
Cancer cytodiagnosis
Cancer screening
Clinical feature
Colposcopy
Controlled study
Endometrium cancer
Female
Follow up
Glandular cell abnormality
Histopathology
Human
Human cell
Human tissue
Liquid based cytology
Major clinical study
Medical record review
Middle aged
Retrospective study
Squamous cell carcinoma
Tertiary care center
Uterine cervix cancer
Uterine cervix cytology
Uterus bleeding