Publication: Neuritogenic and neuroprotective constituents from Aquilaria crassna leaves
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Issued Date
2017
Resource Type
File Type
application/pdf
ISSN
1458884
Other identifier(s)
2-s2.0-85014488684
Rights Holder(s)
Scopus
Bibliographic Citation
Journal of Food Biochemistry. Vol 41, No.3 (2017)
Suggested Citation
Supasuteekul C., Tadtong S., Putalun W., Tanaka H., Likhitwitayawuid K., Tengamnuay P., Sritularak B. Neuritogenic and neuroprotective constituents from Aquilaria crassna leaves. Journal of Food Biochemistry. Vol 41, No.3 (2017). doi:10.1111/jfbc.12365 Retrieved from: https://hdl.handle.net/20.500.14740/4155
Abstract
The leaves of Aquilaria crassna (Thymelaeaceae) are recently become an attractive research due to their potential in antioxidative, antibacterial, antipyretic, analgesic, and laxative activities. However, the neuritogenic and neuroprotective effects of A. crassna leaves have never been reported. In this study, three phenolic glycosides were isolated from A. crassna leaves. The isolates were identified as genkwanin 5-O-β-primevoside (1), iriflophenone 3,5-C-β-d-diglucoside (2) and iriflophenone 3-C-β-d-glucoside (3). The neuroprotective and neuritogenic activities of these compounds were evaluated. Compound 1 and 2, at very low concentration (100 ng/mL of compound 1 and 1 ng/mL of compound 2), exhibited the protection of P19-derived neurons and promoted the neurite outgrowth of the cultured neurons. In addition, a preliminary study on these compounds revealed that there was no correlation between their antioxidative properties and their neuroprotective activities. Practical applications: Agarwood leaves have been used as an ingredient in foods and drinks for health promotion in Asian countries. The results of this study also suggest that Aquilaria crassna leaves are potentially sources of neuritogenic and neuroprotective constituents, which may be developed as functional foods for the prevention of neurodegenerative disorder. © 2017 Wiley Periodicals, Inc.