Publication:
Biomedical and clinical promises of human pluripotent stem cells for neurological disorders

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Issued Date

2013

Resource Type

Review

File Type

application/pdf

ISSN

23146133

DOI

10.1155/2013/656531

Other identifier(s)

2-s2.0-84885573576

Rights Holder(s)

Scopus

Bibliographic Citation

BioMed Research International. Vol 2013, No. (2013), p.-

Suggested Citation

Jongkamonwiwat N., Noisa P. Biomedical and clinical promises of human pluripotent stem cells for neurological disorders. BioMed Research International. Vol 2013, No. (2013), p.-. doi:10.1155/2013/656531 Retrieved from: https://hdl.handle.net/20.500.14740/6532

Title

Biomedical and clinical promises of human pluripotent stem cells for neurological disorders

Author(s)

Jongkamonwiwat N.
 Noisa P.

Abstract

Neurological disorders are characterized by the chronic and progressive loss of neuronal structures and functions. There is a variability of the onsets and causes of clinical manifestations. Cell therapy has brought a new concept to overcome brain diseases, but the advancement of this therapy is limited by the demands of specialized neurons. Human pluripotent stem cells (hPSCs) have been promised as a renewable resource for generating human neurons for both laboratory and clinical purposes. By the modulations of appropriate signalling pathways, desired neuron subtypes can be obtained, and induced pluripotent stem cells (iPSCs) provide genetically matched neurons for treating patients. These hPSC-derived neurons can also be used for disease modeling and drug screening. Since the most urgent problem today in transplantation is the lack of suitable donor organs and tissues, the derivation of neural progenitor cells from hPSCs has opened a new avenue for regenerative medicine. In this review, we summarize the recent reports that show how to generate neural derivatives from hPSCs, and discuss the current evidence of using these cells in animal studies. We also highlight the possibilities and concerns of translating these hPSC-derived neurons for biomedical and clinical uses in order to fight against neurological disorders. © 2013 Nopporn Jongkamonwiwat and Parinya Noisa.

Subject(s)

Biomedicine
 Brain disease
 Cell therapy
 Drug screening
 Human
 Modulation
 Motor neuron disease
 Multiple sclerosis
 Nerve cell
 Neurologic disease
 Nonhuman
 Organ donor
 Parkinson disease
 Pluripotent stem cell
 Review
 Spinal cord injury
 Stem cell
 Stem cell transplantation
 Animal
 Degenerative disease
 Disease model
 Metabolism
 Nerve cell
 Neural stem cell
 Regeneration
 Transplantation
 Animals
 Disease Models, Animal
 Humans
 Neural Stem Cells
 Neurodegenerative Diseases
 Neurons
 Pluripotent Stem Cells
 Regeneration
 Stem Cell Transplantation

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URI

https://hdl.handle.net/20.500.14740/6532

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Scopus: Year 1983-2021

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