Publication:
Statin intensity regimens in Thai type 2 diabetic patients who achieved LDL-C targets

0
0

Issued Date

2017

Resource Type

Article

File Type

application/pdf

ISSN

1252208

Other identifier(s)

2-s2.0-85020839307

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of the Medical Association of Thailand. Vol 100, No.5 (2017), p.603-611

Suggested Citation

Lee B., Dumrongkitchaiporn K., Sriussadaporn S., Thongtang N. Statin intensity regimens in Thai type 2 diabetic patients who achieved LDL-C targets. Journal of the Medical Association of Thailand. Vol 100, No.5 (2017), p.603-611. Retrieved from: https://hdl.handle.net/20.500.14740/4177

Title

Statin intensity regimens in Thai type 2 diabetic patients who achieved LDL-C targets

Author(s)

Lee B.
 Dumrongkitchaiporn K.
 Sriussadaporn S.
 Thongtang N.

Abstract

Background: Type 2 diabetes mellitus (T2D) increases the risk of developing atherosclerotic cardiovascular disease (ASCVD). Statins reduce ASCVD events and are recommended in patients with T2D. Low-, moderate, and high-intensity regimens are predicted to achieve LDL-C reduction by about <30%, 30% to <50%, and ≥50%, respectively. Objective: To investigate the proportions of different statin intensity regimens used in patients with T2D that achieved LDL-C targets. Material and Method: This retrospective cross-sectional study was conducted in 269 T2D adults with LDL-C <100 mg/dL that were stratified into three groups by statin intensity according to 2013 ACC/AHA guideline. Factors significantly associated with higher-intensity statin use were determined by multivariate analysis. Results: Subjects were mostly elderly with long-standing T2D and hypertension (HT). Prevalence of ASCVD was 12.3%. Only 8.9% received high-intensity statins, while 40.9% and 50.2% received low- and moderate-intensity statins, respectively. Overall, attainment of LDL-C <70 mg/dL was 52.8%. Average LDL-C reduction was 54.6% (49.6%, 54.4%, and 59.7% in the low-, moderate-, and high-intensity groups, respectively). Rates of ASCVD, HT, and smoking were higher in the highintensity group. Factors significantly correlated with higher-intensity statin therapy included diabetic nephropathy (DN), HT, high-density lipoprotein cholesterol (HDL-C), and non-HDL-C levels (OR: 2.633, 2.381, 1.027, and 1.037, respectively). Conclusion: Low- and moderate-intensity statin users accounted for about 90% of Thai T2D patients who achieved LDL-C <100 mg/dL. LDL-C reduction in these two groups was greater than anticipated. HT and DN were associated with the use of higher-intensity statins to achieve LDL-C targets. © 2017, Medical Association of Thailand. All rights reserved.

Subject(s)

Apolipoprotein B
 Atorvastatin
 Ezetimibe plus simvastatin
 Hemoglobin A1c
 High density lipoprotein cholesterol
 Hydroxymethylglutaryl coenzyme A reductase inhibitor
 Low density lipoprotein
 Rosuvastatin
 Triacylglycerol
 Add on therapy
 Adult
 Article
 Biochemical analysis
 Colorimetry
 Cross-sectional study
 Diabetic nephropathy
 Diabetic patient
 Drug megadose
 Female
 Glycemic control
 Human
 Hyperlipidemia
 Hypertension
 Low drug dose
 Major clinical study
 Male
 Microangiopathy
 Middle aged
 Non insulin dependent diabetes mellitus
 Prevalence
 Retrospective study
 Risk factor
 Smoking
 Turbidimetry

View online Resources

Research Projects

Organizational Units

Journal Issue

URI

https://hdl.handle.net/20.500.14740/4177

Collections

Scopus: Year 1983-2021

Endorsement

Review

Supplemented By

Referenced By